a Department of Food Science and Engineering, Institute of Food Safety and Nutrition, Guangdong Engineering Technology Center of Food Safety Molecular Rapid Detection , Jinan University , Guangzhou , PR China.
b School of Chemical Engineering and Light Industry , Guangdong University of Technology , Guangzhou , PR China.
Crit Rev Food Sci Nutr. 2019;59(6):921-946. doi: 10.1080/10408398.2018.1491022. Epub 2018 Dec 3.
Metabolic syndrome develops to several related chronic diseases, such as obesity, cardiovascular disease, hypertension, diabetes, and fatty liver disease. Diseases are outcomes of various cells dysfunction, which are especially acting with a network in metabolic syndrome. Anthocyanins are natural edible pigments widely existed in dark-colored fruits, vegetables, and grains. Epidemiological investigation and nutritional intervention of anthocyanins have exhibited broad-spectrum biological effects that they can benefit patients with metabolic syndrome related chronic diseases. Whereas the underlying mechanisms and the effects of anthocyanins on critical cells in chronic metabolic diseases are complex and elusive. Therefore, this review summarizes the studies about the effects of anthocyanins on various metabolism related chronic diseases, and mainly focuses on the effects and underlying molecular mechanisms on critical cells. We confirmed that anthocyanins are efficient on adipocytes, endothelial cells, inflammatory cells, hepatocytes, intestinal cells and gut microbiota, but lack of evidence on platelets, skeletal muscle cells, hepatic stellate cells and pancreatic beta cells. Additionally, we discussed the structure-function relationship of anthocyanins and the metabolites. This review summarizes the development of studies on anthocyanins with its target cells in metabolic syndrome, and discusses the unclear aspects of the anthocyanins research work, which is necessary for the future clinical application.
代谢综合征会发展成几种相关的慢性疾病，如肥胖、心血管疾病、高血压、糖尿病和脂肪肝疾病。这些疾病是多种细胞功能障碍的结果，在代谢综合征中尤其以网络的形式发挥作用。花色苷是天然存在于深色水果、蔬菜和谷物中的可食用色素。花色苷的流行病学调查和营养干预已经表现出广泛的生物效应，它们可以使代谢综合征相关慢性疾病患者受益。然而，花色苷对慢性代谢性疾病关键细胞的作用机制和影响是复杂且难以捉摸的。因此，本综述总结了花色苷对各种与代谢相关的慢性疾病的影响的研究，主要集中在花色苷对关键细胞的作用及其潜在的分子机制上。我们证实花色苷对脂肪细胞、内皮细胞、炎症细胞、肝细胞、肠细胞和肠道微生物群有效，但对血小板、骨骼肌细胞、肝星状细胞和胰腺β细胞缺乏证据。此外，我们还讨论了花色苷的结构-功能关系及其代谢物。本综述总结了代谢综合征中花色苷及其靶细胞的研究进展，并讨论了花色苷研究工作中不清楚的方面，这对未来的临床应用是必要的。
