a School of Pharmacy, Jiangsu Key Laboratory of Inflammation and Molecular Drug Targets , Nantong University , Nantong , China.
b Department of Chemistry , Qilu Normal University , Jinan , China.
J Drug Target. 2019 Feb;27(2):201-210. doi: 10.1080/1061186X.2018.1499746. Epub 2018 Aug 20.
Combined chemo-photothermal therapy is attracting increasing attention in the treatment of cancers. In this work, PEGylated mesoporous SiO-coated gold nanostars (GNS@mSiO-PEG) were synthesised without using the cytotoxic surfactant cetyltrimethylammonium bromide as the template. Mesoporous nanostructures were obtained by poly(vinylpyrrolidone) protection of the outer silica shell and NaOH etching of the inner shell. GNS@mSiO-PEG exhibited good dispersity in medium and excellent photothermal effects. Loading capacity for the anticancer drug doxorubicin (DOX) was ∼17.9%, and the drug release profile was pH- and light-responsive. In vitro studies revealed that the as-prepared nanocomposites featured good biocompatibility. Furthermore, the nanocomposites were readily internalised by cancer cells, and a combined chemo-photothermal therapy assay revealed that DOX-loaded GNS@mSiO-PEG have a higher therapeutic efficiency than individual therapies, demonstrating suitable synergistic effects.
联合化疗-光热疗法在癌症治疗中越来越受到关注。在这项工作中，我们合成了一种没有使用细胞毒性表面活性剂十六烷基三甲基溴化铵作为模板的聚乙二醇化介孔硅包覆金纳米星（GNS@mSiO-PEG）。介孔纳米结构是通过聚（乙烯基吡咯烷酮）对外壳硅的保护和内壳 NaOH 的刻蚀得到的。GNS@mSiO-PEG 在介质中具有良好的分散性和优异的光热效应。载药量约为 17.9%，药物释放呈 pH 和光响应性。体外研究表明，所制备的纳米复合材料具有良好的生物相容性。此外，这些纳米复合材料很容易被癌细胞内化，联合化疗-光热治疗实验表明，载药 GNS@mSiO-PEG 的治疗效率高于单一疗法，显示出合适的协同作用。
