IEEE Trans Ultrason Ferroelectr Freq Control. 2018 Aug;65(8):1380-1388. doi: 10.1109/TUFFC.2018.2841774. Epub 2018 May 28.
Direct ultrasonic imaging of arterial and venous thrombi could aid in diagnosis and treatment planning by providing rapid and cost-effective measurements of thrombus volume and elastic modulus. Toward this end, it was demonstrated that open-air magnetomotive ultrasound (MMUS) provides specific contrast to superparamagnetic iron oxide-labeled model thrombi embedded in gelatin-based blood vessel-mimicking flow phantoms. MMUS was performed on model thrombi in the presence of pulsatile flow that mimics cardiac-induced motion found in real vasculature. The MMUS signal and contrast-to-noise ratio (CNR) were measured across a range of physiologically relevant thrombus volumes and elastic moduli. Model thrombus volumes as small as 0.5 ml were shown to be detectable (CNR > 1) over the entire range of elastic moduli tested (3.5-40 kPa). It was also found that MMUS signal and CNR are increased with increasing thrombus volume ( ) and decreasing elastic modulus ( ), while variations in pulsatile flow rate had little effect. These findings demonstrate that MMUS has promise as a direct in vivo thrombosis imaging modality for quantifying thrombus volume and stiffness.
直接超声成像动脉和静脉血栓可以通过提供血栓体积和弹性模量的快速和具有成本效益的测量来辅助诊断和治疗计划。为此，已经证明开放空气磁动超声（MMUS）为嵌入明胶基血管模拟流动体模中的超顺磁性氧化铁标记的模型血栓提供了特定的对比。在模拟心脏诱导运动的脉动流存在的情况下，对模型血栓进行了 MMUS 检查，这种运动在真实血管中发现。在一系列与生理相关的血栓体积和弹性模量范围内测量了 MMUS 信号和对比噪声比（CNR）。结果表明，在整个测试的弹性模量范围内（3.5-40 kPa），体积小至 0.5 ml 的模型血栓均具有可检测性（CNR > 1）。还发现，随着血栓体积（）的增加和弹性模量（）的降低，MMUS 信号和 CNR 增加，而脉动流速的变化影响很小。这些发现表明，MMUS 有望成为一种直接的体内血栓成像方式，用于定量血栓体积和硬度。
