Center for Biomimetic Medicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.
Department of Orthopedic & Sports Medicine, The Houston Methodist Hospital, Houston, TX, 77030, USA.
Adv Healthc Mater. 2018 Sep;7(17):e1800490. doi: 10.1002/adhm.201800490. Epub 2018 Jul 11.
Regenerative medicine technologies rely heavily on the use of well-designed biomaterials for therapeutic applications. The success of implantable biomaterials hinges upon the ability of the chosen biomaterial to negotiate with the biological barriers in vivo. The most significant of these barriers is the immune system, which is composed of a highly coordinated organization of cells that induce an inflammatory response to the implanted biomaterial. Biomimetic platforms have emerged as novel strategies that aim to use the principle of biomimicry as a means of immunomodulation. This principle has manifested itself in the form of biomimetic scaffolds that imitate the composition and structure of biological cells and tissues. Recent work in this area has demonstrated the promising potential these technologies hold in overcoming the barrier of the immune system and, thereby, improve their overall therapeutic efficacy. In this review, a broad overview of the use of these strategies across several diseases and future avenues of research utilizing these platforms is provided.
再生医学技术在很大程度上依赖于设计良好的生物材料在治疗中的应用。可植入生物材料的成功取决于所选生物材料与体内生物屏障进行协商的能力。其中最重要的屏障是免疫系统，它由高度协调的细胞组织组成，会对植入的生物材料产生炎症反应。仿生平台已成为一种新的策略，旨在利用仿生学原理作为免疫调节的一种手段。这一原理表现为模仿生物细胞和组织组成和结构的仿生支架。该领域的最新研究表明，这些技术在克服免疫系统障碍方面具有广阔的应用前景，从而提高了其整体治疗效果。在这篇综述中，提供了这些策略在几种疾病中的广泛应用以及利用这些平台的未来研究方向的概述。
