Gabius H J, Engelhardt R, Cramer F
Med Hypotheses. 1985 Sep;18(1):47-50. doi: 10.1016/0306-9877(85)90118-5.
Endogenous lectins of normal tissues can play a functional role in recognition processes and cell adhesion. These functions are areas of particular relevance to tumor growth and metastasis. Our initial results on endogenous lectins of different tumors lead to the working hypothesis that the pattern of endogenous lectins is qualitatively and quantitatively different between different types of tumors and between tumors and normal, nonmalignant tissues. The endogenous lectins may thus prove to be potentially important in establishing a new concept for a rational lectin-based type of diagnosis and therapy of various tumors.
正常组织的内源性凝集素可在识别过程和细胞黏附中发挥功能作用。这些功能与肿瘤生长和转移密切相关。我们对不同肿瘤内源性凝集素的初步研究结果得出一个工作假设，即不同类型肿瘤之间以及肿瘤与正常非恶性组织之间，内源性凝集素的模式在质和量上均存在差异。因此，内源性凝集素可能在建立基于凝集素的各种肿瘤合理诊断和治疗新观念方面具有潜在重要性。
