通过输注阿拉伯半乳聚糖和 D-半乳糖阻断肝细胞凝集素对小鼠肝转移的抑制作用。
Inhibition of liver metastasis in mice by blocking hepatocyte lectins with arabinogalactan infusions and D-galactose.
作者信息
Beuth J, Ko H L, Oette K, Pulverer G, Roszkowski K, Uhlenbruck G
出版信息
J Cancer Res Clin Oncol. 1987;113(1):51-5. doi: 10.1007/BF00389966.
Abstract
According to our hypothesis, organ-specific lectins (e.g., the D-galactose-specific hepatic binding protein) play an important role in the organ location of metastatic malignant cells. The rapid clearance and uptake by the liver of tritiated alpha 1-acid-(asialo)glycoprotein from the circulation of Balb/c mice was markedly delayed after preinjection of D-galactose or arabinogalactan. The preinjection (1 h) and regular application (for 3 days after tumor cell inoculation in Balb/c mice) of the receptor blocking agents D-galactose and arabinogalactan prevented the settling of sarcoma L-1 tumor in the liver completely, but did not influence the settling in the lung. Other galactans, dextrans, and phosphate-buffered saline showed no effect. Therefore, when lectins were blocked with competitive-specific glycoconjugates, colonization was prevented.
摘要
根据我们的假设，器官特异性凝集素（例如，D-半乳糖特异性肝结合蛋白）在转移性恶性细胞的器官定位中起重要作用。在预先注射D-半乳糖或阿拉伯半乳聚糖后，Balb/c小鼠循环中的氚标记α1-酸性（去唾液酸）糖蛋白被肝脏快速清除和摄取的过程明显延迟。受体阻断剂D-半乳糖和阿拉伯半乳聚糖的预先注射（1小时）以及定期应用（在Balb/c小鼠接种肿瘤细胞后3天）完全阻止了L-1肉瘤在肝脏中的定植，但不影响其在肺部的定植。其他半乳聚糖、葡聚糖和磷酸盐缓冲盐水则无此作用。因此，当凝集素被竞争性特异性糖缀合物阻断时，定植就会被阻止。
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本文引用的文献
1
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2
The Thomsen-Friedenreich (TF) receptor: an old history with new mystery.汤姆森-弗里德赖希（TF）受体：一段有着新谜团的古老历史。
Immunol Commun. 1981;10(3):251-64. doi: 10.3109/08820138109093459.
3
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Naturwissenschaften. 1983 Feb;70(2):98-9. doi: 10.1007/BF00365514.
4
Macrophage-mediated destruction of malignant tumor cells and new strategies for the therapy of metastatic disease.巨噬细胞介导的恶性肿瘤细胞破坏及转移性疾病治疗的新策略。
Springer Semin Immunopathol. 1982;5(2):161-74. doi: 10.1007/BF00199794.
5
Liver lectins: mediators for metastases?肝脏凝集素：转移的介质？
Experientia. 1983 Nov 15;39(11):1314-5. doi: 10.1007/BF01990389.
6
Proposed molecular basis of murine tumor cell-hepatocyte interaction.小鼠肿瘤细胞与肝细胞相互作用的分子基础假说。
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7
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10
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J Biol Chem. 1971 Aug 10;246(15):4825-33.
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