人类β-珠蛋白基因3'端附近KpnI家族成员的序列分析。
Sequence analysis of a KpnI family member near the 3' end of human beta-globin gene.
作者信息
Hattori M, Hidaka S, Sakaki Y
出版信息
Nucleic Acids Res. 1985 Nov 11;13(21):7813-27. doi: 10.1093/nar/13.21.7813.
Abstract
We determined the complete nucleotide sequence (6125 bp) of a full-length member of human KpnI family, designated T beta G41, which is located about 3 kb downstream from the beta-globin gene. Comparison of the sequence with the KpnI family sequence compiled by Singer revealed that a new 131 bp sequence is present in the T beta G41. Hybridization analyses showed that a few thousand of human KpnI family members are carrying this additional sequence. Computer search of DNA databases for T beta G41-homologous sequence showed that some T beta G41-homologous sequences were closely associated with pseudogenes. The T beta G41 sequence also showed significant sequence homology with ChBlym-1, a transferrin-like transforming gene of chicken. Furthermore, an amino acid sequence deduced from the T beta G41 nucleotide sequence revealed a relatively-high homology to those of human transferrin and lactotransferrin.
摘要
我们测定了人类KpnI家族一个全长成员（命名为TβG41）的完整核苷酸序列（6125 bp），该成员位于β-珠蛋白基因下游约3 kb处。将该序列与Singer汇编的KpnI家族序列进行比较，发现TβG41中存在一个新的131 bp序列。杂交分析表明，数千个人类KpnI家族成员携带这一额外序列。在DNA数据库中对TβG41同源序列进行计算机搜索，结果显示一些TβG41同源序列与假基因密切相关。TβG41序列还与鸡的转铁蛋白样转化基因ChBlym-1表现出显著的序列同源性。此外，从TβG41核苷酸序列推导的氨基酸序列显示与人类转铁蛋白和乳铁转铁蛋白的氨基酸序列具有较高的同源性。
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2
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FEBS Lett. 1982 Jun 1;142(1):107-10. doi: 10.1016/0014-5793(82)80229-9.
3
A new family of interspersed repetitive DNA sequences in the mouse genome.小鼠基因组中一个新的散布重复DNA序列家族。
J Mol Biol. 1982 May 25;157(3):453-71. doi: 10.1016/0022-2836(82)90471-5.
4
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6
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7
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8
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9
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