在人类基因组中，一些KpnI家族成员与Alu家族相关联。
Some KpnI family members are associated with the Alu family in the human genome.
作者信息
Miyake T, Migita K, Sakaki Y
出版信息
Nucleic Acids Res. 1983 Oct 11;11(19):6837-46. doi: 10.1093/nar/11.19.6837.
Abstract
The structures of the termini and their flanking regions of two human KpnI family members were investigated. The two differed in length, but the starting sequence at one terminal (defined as the 5' terminal) was found to be common to both members. The Alu family sequence was found in the 5' flanking regions. The KpnI family sequence started several base-pairs downstream from the 3' end of the Alu family sequence. In both cases, the Alu family sequence was not flanked by the direct repeat sequence common to the Alu family. These two members showed no sequence homology in 3' terminal regions. Interestingly, the Alu family plus the KpnI family unit was found to be flanked by a direct repeat sequence of several base-pair length. Based on these findings, relationship between the Alu family and KpnI family is discussed.
摘要
对两个人类KpnI家族成员的末端及其侧翼区域的结构进行了研究。两者长度不同，但发现其中一个末端（定义为5'末端）的起始序列在两个成员中是相同的。在5'侧翼区域发现了Alu家族序列。KpnI家族序列从Alu家族序列3'端下游几个碱基对处开始。在这两种情况下，Alu家族序列两侧都没有Alu家族常见的直接重复序列。这两个成员在3'末端区域没有序列同源性。有趣的是，发现Alu家族加上KpnI家族单元两侧有几个碱基对长度的直接重复序列。基于这些发现，讨论了Alu家族与KpnI家族之间的关系。
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