Johan Arief Muhammad Faiz, Choo Brandon Kar Meng, Yap Jia Ling, Kumari Yatinesh, Shaikh Mohd Farooq
MBBS Young Scholars Program, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.
Neuropharmacology Research Laboratory, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Malaysia.
Front Pharmacol. 2018 Jun 27;9:655. doi: 10.3389/fphar.2018.00655. eCollection 2018.
Epilepsy is a common neurological disorder characterized by seizures which result in distinctive neurobiological and behavioral impairments. Not much is known about the causes of epilepsy, making it difficult to devise an effective cure for epilepsy. Moreover, clinical studies involving epileptogenesis and ictogenesis cannot be conducted in humans due to ethical reasons. As a result, animal models play a crucial role in the replication of epileptic seizures. In recent years, non-mammalian models have been given a primary focus in epilepsy research due to their advantages. This systematic review aims to summarize the importance of non-mammalian models in epilepsy research, such as in the screening of anti-convulsive compounds. The reason for this review is to integrate currently available information on the use and importance of non-mammalian models in epilepsy testing to aid in the planning of future studies as well as to provide an overview of the current state of this field. A PRISMA model was utilized and PubMed, Springer, ScienceDirect and SCOPUS were searched for articles published between January 2007 and November 2017. Fifty-one articles were finalized based on the inclusion/exclusion criteria and were discussed in this review. The results of this review demonstrated the current use of non-mammalian models in epilepsy research and reaffirmed their potential to supplement the typical rodent models of epilepsy in future research into both epileptogenesis and the treatment of epilepsy. This review also revealed a preference for zebrafish and fruit flies in lieu of other non-mammalian models, which is a shortcoming that should be corrected in future studies due to the great potential of these underutilized animal models.
癫痫是一种常见的神经系统疾病，其特征为发作，会导致独特的神经生物学和行为障碍。人们对癫痫的病因了解不多，因此难以设计出有效的癫痫治疗方法。此外，由于伦理原因，涉及癫痫发生和发作过程的临床研究无法在人类身上进行。因此，动物模型在癫痫发作的复制中起着至关重要的作用。近年来，非哺乳动物模型因其优势在癫痫研究中受到了主要关注。本系统综述旨在总结非哺乳动物模型在癫痫研究中的重要性，例如在抗惊厥化合物的筛选方面。进行这项综述的原因是整合目前关于非哺乳动物模型在癫痫测试中的使用和重要性的可用信息，以帮助规划未来的研究，并概述该领域的当前状态。使用了PRISMA模型，并在PubMed、Springer、ScienceDirect和SCOPUS中搜索了2007年1月至2017年11月发表的文章。根据纳入/排除标准最终确定了51篇文章，并在本综述中进行了讨论。本综述的结果展示了非哺乳动物模型在癫痫研究中的当前应用，并再次确认了它们在未来癫痫发生和癫痫治疗研究中补充典型癫痫啮齿动物模型的潜力。本综述还揭示了相较于其他非哺乳动物模型，对斑马鱼和果蝇的偏好，由于这些未充分利用的动物模型具有巨大潜力，这一缺点在未来研究中应予以纠正。
