Domínguez-Sanchéz María A, Bustos-Cruz Rosa H, Velasco-Orjuela Gina P, Quintero Andrea P, Tordecilla-Sanders Alejandra, Correa-Bautista Jorge E, Triana-Reina Héctor R, García-Hermoso Antonio, González-Ruíz Katherine, Peña-Guzmán Carlos A, Hernández Enrique, Peña-Ibagon Jhonatan C, Téllez-T Luis A, Izquierdo Mikel, Ramírez-Vélez Robinson
Grupo de Investigación Movimiento Corporal Humano, Facultad de Enfermería y Rehabilitación, Universidad de La Sabana, Chía, Colombia.
Evidence-Based Therapeutic Group, Clinical Pharmacology, Universidad de La Sabana, Bogotá, Colombia.
Front Physiol. 2018 Jun 27;9:741. doi: 10.3389/fphys.2018.00741. eCollection 2018.
The purpose of this study was to compare the neurotrophic factor response following one session of high-intensity exercise, resistance training or both in a cohort of physically inactive overweight adults aged 18-30 years old. A randomized, parallel-group clinical trial of 51 men (23.6 ± 3.5 years; 83.5 ± 7.8 kg; 28.0 ± 1.9 kg/m) who are physically inactive (i.e., < 150 min of moderate-intensity exercise per week or IPAQ score of <600 MET min/week for >6 months) and are either abdominally obese (waist circumference ≥90 cm) or have a body mass index, BMI ≥25 and ≤ 30 kg/m were randomized to the following four exercise protocols: high-intensity exercise (4 × 4 min intervals at 85-95% maximum heart rate [HRmax] interspersed with 4 min of recovery at 75-85% HRmax) ( = 14), resistance training (12-15 repetitions per set, at 50-70% of one repetition maximum with 60 s of recovery) ( = 12), combined high-intensity and resistance exercise ( = 13), or non-exercising control ( = 12). The plasma levels of neurotrophin-3 (NT-3), neurotrophin-4 (also known as neurotrophin 4/5; NT-4 or NT-4/5), and brain-derived neurotrophic factor (BDNF) were determined before (pre-exercise) and 1-min post-exercise for each protocol session. Resistance training induced significant increases in NT-3 (+39.6 ng/mL [95% CI, 2.5-76.6; = 0.004], and NT-4/5 (+1.3 ng/mL [95% CI, 0.3-2.3; = 0.014]), respectively. Additionally, combined training results in favorable effects on BDNF (+22.0, 95% CI, 2.6-41.5; = 0.029) and NT-3 (+32.9 ng/mL [95% CI, 12.3-53.4; = 0.004]), respectively. The regression analysis revealed a significant positive relationship between changes in BDNF levels and changes in NT-4/5 levels from baseline to immediate post-exercise in the combined training group ( = 0.345, = 0.034) but not the other intervention groups. The findings indicate that acute resistance training and combined exercise increase neurotrophic factors in physically inactive overweight adults. Further studies are required to determine the biological importance of changes in neurotrophic responses in overweight men and chronic effects of these exercise protocols.
ClinicalTrials.gov, NCT02915913 (Date: September 22, 2016).
本研究的目的是比较在一组年龄为18 - 30岁、身体不活跃的超重成年人中，进行一次高强度运动、阻力训练或两者结合后神经营养因子的反应。对51名男性（23.6±3.5岁；83.5±7.8千克；28.0±1.9千克/米²）进行了一项随机平行组临床试验，这些男性身体不活跃（即每周中等强度运动少于150分钟或IPAQ评分低于600代谢当量分钟/周超过6个月），且要么腹部肥胖（腰围≥90厘米），要么体重指数（BMI）≥25且≤30千克/米²，他们被随机分配到以下四种运动方案：高强度运动（以最大心率[HRmax]的85 - 95%进行4×4分钟的间歇，中间穿插以HRmax的75 - 85%进行4分钟的恢复）（n = 14）、阻力训练（每组12 - 15次重复，以一次重复最大值的50 - 70%进行，恢复60秒）（n = 12）、高强度和阻力联合运动（n = 13）或不运动对照组（n = 12）。在每个方案训练前（运动前）和运动后1分钟测定血浆中神经营养因子-3（NT - 3）、神经营养因子-4（也称为神经营养因子4/5；NT - 4或NT - 4/5）和脑源性神经营养因子（BDNF）的水平。阻力训练分别使NT - 3显著增加（+39.6纳克/毫升[95%置信区间，2.5 - 76.6；P = 0.004]）和NT - 4/5显著增加（+1.3纳克/毫升[95%置信区间，0.3 - 2.3；P = 0.014]）。此外，联合训练分别对BDNF（+22.0，95%置信区间，2.6 - 41.5；P = 0.029）和NT - 3（+32.9纳克/毫升[95%置信区间，12.3 - 53.4；P = 0.004]）产生有利影响。回归分析显示，在联合训练组中，从基线到运动后即刻，BDNF水平变化与NT - 4/5水平变化之间存在显著正相关（r = 0.345，P = 0.034），但在其他干预组中未发现这种相关性。研究结果表明，急性阻力训练和联合运动可增加身体不活跃的超重成年人中的神经营养因子。需要进一步研究来确定超重男性神经营养反应变化的生物学重要性以及这些运动方案的长期影响。
ClinicalTrials.gov，NCT02915913（日期：2016年9月22日）。
