Sato Kae, Sato Kiichi
Department of Chemical and Biological Sciences, Faculty of Science, Japan Women's University.
Department of Chemistry and Chemical Biology, School of Science and Technology, Gunma University.
Anal Sci. 2018;34(7):755-764. doi: 10.2116/analsci.17R006.
The blood vessel is part of the circulatory system, and systemic circulation provides the blood supply to all tissues. Arteries are pathways through which the blood is carried, and the capillaries have a key role in material exchange to maintain the tissue environment. Blood vessels have structures appropriate for their functions, and their sizes and cell types are different. In this review, we introduced recent studies of the microfluidic vascular models. The model structures are classified mainly as poly(dimethylsiloxane) and hydrogel microchannels and self-assembled networks. Basic phenomena and functions were realized in vascular models, including fluid shear stress, cell strain, interstitial flow, endothelial permeation, angiogenesis, and thrombosis. In some models, endothelial cells were co-cultured with smooth muscle cells, pericytes, and fibroblasts in an extracellular matrix. Examples of vascular models involving the brain, lung, liver, kidney, placenta, and cancer were also introduced.
血管是循环系统的一部分，体循环为所有组织提供血液供应。动脉是血液运输的通道，而毛细血管在物质交换以维持组织环境方面起着关键作用。血管具有与其功能相适应的结构，其大小和细胞类型各不相同。在本综述中，我们介绍了微流控血管模型的最新研究。模型结构主要分为聚二甲基硅氧烷和水凝胶微通道以及自组装网络。血管模型实现了包括流体剪切应力、细胞应变、间质流、内皮渗透、血管生成和血栓形成等基本现象和功能。在一些模型中，内皮细胞与平滑肌细胞、周细胞和成纤维细胞在细胞外基质中共培养。还介绍了涉及脑、肺、肝、肾、胎盘和癌症的血管模型实例。
