Brain and Behavioral Sciences, University of Georgia, Athens, Georgia, United States of America.
Institute of Gerontology, University of Georgia, Athens, Georgia, United States of America.
PLoS One. 2018 Jul 12;13(7):e0199940. doi: 10.1371/journal.pone.0199940. eCollection 2018.
Data obtained mostly from animal models and ex vivo samples show that a small portion of ultraviolet light (UV, 300-400 nm) penetrates the cornea and crystalline lens and impinges on the human retina. UV transmission to the retina appears to be unique to the young and some older pseudophakes. In this study, we determine the variation in UV transmission in a relatively homogenous sample of young adults.
42 subjects were tested (M = 19 ± 1.3 years). Absolute thresholds to UV radiation were collected (λmax = 315 nm, 305-325). Macular pigment optical density (MPOD, measured using heterochromatic flicker photometry) and iris color (using a standardized color scale) were also assessed as potential covariates.
All of the subjects could detect UV radiation at 315 nm but individual variation was large (over a factor of 30). Higher MPOD and darker iridies were not related to UV sensitivity in this young sample. Males, however, were more sensitive to UV than the females (p<0.05).
The large individual differences in UV reaching the retina of younger individuals suggests equally significant vulnerability to the actinic effects of this highly energetic light.
主要来源于动物模型和离体样本的数据表明，一小部分紫外线（UV，300-400nm）穿透角膜和晶状体并撞击人眼视网膜。UV 对视网膜的穿透似乎是年轻人和一些较老的人工晶状体眼所特有的。在这项研究中，我们确定了相对同质的年轻成年人样本中 UV 透射的变化。
对 42 名受试者进行了测试（M=19±1.3 岁）。收集了 UV 辐射的绝对阈值（λmax=315nm，305-325nm）。还评估了黄斑色素光学密度（MPOD，使用异相闪烁光度法测量）和虹膜颜色（使用标准化颜色量表）作为潜在的协变量。
所有受试者均能在 315nm 处检测到 UV 辐射，但个体差异较大（超过 30 倍）。在这个年轻的样本中，较高的 MPOD 和较暗的虹膜颜色与 UV 敏感性无关。然而，男性比女性对 UV 更敏感（p<0.05）。
年轻个体视网膜接收到的 UV 存在较大的个体差异，表明他们对这种高能量光的光化作用同样具有显著的脆弱性。
