Bullarbo Maria, Mattson Helena, Broman Anna-Karin, Ödman Natalia, Nielsen Thorkild F
Department of Obstetrics and Gynecology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Department of Gynecology, Närhälsan, Mölndal, Sweden.
J Pregnancy. 2018 May 29;2018:4843159. doi: 10.1155/2018/4843159. eCollection 2018.
To investigate the effect of magnesium (Mg) supplementation in healthy pregnant women for prevention of blood pressure increase. Secondary outcomes were comparison of biomarkers for hypertensive disorders and labour and fetal outcomes between the groups.
Two hundred nulliparous healthy pregnant women were double-blind randomized to receive Mg daily or placebo.
There were no differences in blood pressure increase. However, among the Mg-treated women, there was a significant negative correlation between increase in blood levels of magnesium and increase in systolic blood pressure ( = 0.042). Magnesium supplementation seems to be safe for both mother and infant.
Magnesium supplementation in healthy first-time pregnant women is not to be recommended for prevention of blood pressure increase. Supplementation in risk pregnancies needs to be further investigated. The study is listed on the ISRCTN registry with study ID 13890849.
研究补充镁（Mg）对健康孕妇预防血压升高的效果。次要结果是比较两组间高血压疾病的生物标志物、分娩及胎儿结局。
200名未生育的健康孕妇被双盲随机分组，分别每日接受镁或安慰剂。
血压升高情况无差异。然而，在接受镁治疗的女性中，血液镁水平升高与收缩压升高之间存在显著负相关（P = 0.042）。补充镁对母婴似乎都是安全的。
不建议健康初产妇补充镁来预防血压升高。有风险妊娠的补充情况需要进一步研究。该研究已在国际标准随机对照试验编号注册库注册，研究编号为13890849。
