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利用L.提取物绿色合成银纳米颗粒，作为一种潜在的抗病毒剂，用于对抗鸡的传染性喉气管炎病毒和传染性支气管炎病毒。

Green synthesized silver nanoparticles using L. extract as a potential antiviral agent against infectious laryngotracheitis and infectious bronchitis viruses in chickens.

作者信息

Abo-El-Yazid Zahraa Hamdi, Ahmed Osama Konsowa, El-Tholoth Mohamed, Ali Mohamed Abdel-Shakur

机构信息

Biochemistry Department, Faculty of Agriculture, Cairo University, Giza, Egypt.

Department of Virology, Faculty of Veterinary Medicine, Mansoura University, Mansoura, 35516 Egypt.

出版信息

Chem Biol Technol Agric. 2022;9(1):55. doi: 10.1186/s40538-022-00325-z. Epub 2022 Aug 12.

DOI:10.1186/s40538-022-00325-z
PMID:37520583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9372957/
Abstract

BACKGROUND

Infectious laryngotracheitis (ILT) and infectious bronchitis (IB) are two common respiratory diseases of poultry that inflict great economic burden on the poultry industry. Developing an effective agent against both viruses is a crucial step to decrease the economic losses. Therefore, for the first time green synthesized silver nanoparticles using L aqueous extract was evaluated in vitro as a potential antiviral against both viruses.

RESULTS

Silver nanoparticles from were characterized by the spherical shape, 11-19 nm size, and zeta potential of - 6.04 mV. The maximum nontoxic concentration (MNTC) was 50 µg mL for both viruses without harmful toxicity impact. The study suggested that some of the compounds in extract (gallic acid, chlorogenic acid, and naringenin) or its silver nanoparticles could interact with the external envelope proteins of both viruses, and inhibiting extracellular viruses.

CONCLUSIONS

The results highlight that green synthesized silver nanoparticles could have antiviral activity against infectious laryngotracheitis virus (ILTV) and infectious bronchitis virus (IBV) in chickens.

摘要

背景

传染性喉气管炎（ILT）和传染性支气管炎（IB）是家禽的两种常见呼吸道疾病，给家禽业带来巨大经济负担。开发一种针对这两种病毒的有效制剂是减少经济损失的关键一步。因此，首次对使用L水提取物绿色合成的银纳米颗粒进行了体外评估，以确定其作为针对这两种病毒的潜在抗病毒剂的效果。

结果

所制备的银纳米颗粒呈球形，尺寸为11 - 19纳米，zeta电位为 - 6.04毫伏。两种病毒的最大无毒浓度（MNTC）均为50微克/毫升，且无有害毒性影响。研究表明，L提取物中的某些化合物（没食子酸、绿原酸和柚皮苷）或其银纳米颗粒可能与两种病毒的外膜蛋白相互作用，从而抑制细胞外病毒。

结论

结果表明，L绿色合成的银纳米颗粒可能对鸡的传染性喉气管炎病毒（ILTV）和传染性支气管炎病毒（IBV）具有抗病毒活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/af360525fb0e/40538_2022_325_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/bf1c09bfcbd3/40538_2022_325_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/3cf8a04e6565/40538_2022_325_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/0660f8bce450/40538_2022_325_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/cefcb223546f/40538_2022_325_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/af360525fb0e/40538_2022_325_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/bf1c09bfcbd3/40538_2022_325_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/3cf8a04e6565/40538_2022_325_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/0660f8bce450/40538_2022_325_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/cefcb223546f/40538_2022_325_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0cb2/9372957/af360525fb0e/40538_2022_325_Fig5_HTML.jpg

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