Henrikson Nora B, Zhu Weiwei, Baba Lauren, Nguyen Matthew, Berthoud Heidi, Gundersen Gabrielle, Hofstetter Annika M
1 Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
2 University of Washington, Seattle, WA, USA.
Clin Pediatr (Phila). 2018 Nov;57(13):1523-1531. doi: 10.1177/0009922818787868. Epub 2018 Jul 13.
This study evaluated the impact of health system-based outreach and reminders on human papillomavirus (HPV) vaccine series initiation and completion. Parents of 10 to 12 year olds (n = 1805) were randomized to receive either (1) an outreach letter and brochure recommending HPV vaccination followed by automated HPV vaccine reminders or (2) usual care. We interviewed a subset of 50 parents to assess program acceptability. Outcomes were HPV vaccine initiation during the study period and on-time series completion. Rates of HPV vaccine initiation during the study period (July 2015 to August 2016) were similar between the intervention and control groups, but initiation within 120 days of randomization was higher in the intervention group (23.6% and 18.8%, P = .04) as was completion during the study period (10.3% vs 6.8%, P = .04). Reminders for doses 2 and 3 did not affect completion. The program was acceptable to parents. This study provides evidence that health system-based outreach and reminders can improve HPV vaccination.
本研究评估了基于卫生系统的外展服务和提醒对人乳头瘤病毒（HPV）疫苗系列接种起始和完成情况的影响。10至12岁儿童的家长（n = 1805）被随机分为两组，一组接受（1）一封推荐HPV疫苗接种的外展信和宣传册，随后是HPV疫苗自动提醒，另一组接受（2）常规护理。我们对50名家长进行了访谈，以评估该项目的可接受性。结果指标为研究期间的HPV疫苗接种起始情况和按时完成系列接种情况。在研究期间（2015年7月至2016年8月），干预组和对照组的HPV疫苗接种起始率相似，但干预组在随机分组后120天内的接种起始率更高（分别为23.6%和18.8%，P = 0.04），研究期间的完成率也是如此（分别为10.3%和6.8%，P = 0.04）。第2剂和第3剂的提醒并未影响完成率。该项目为家长所接受。本研究提供了证据，表明基于卫生系统的外展服务和提醒可改善HPV疫苗接种情况。
