Al-Otaibi Fahed S, Ajarem Jamaan S, Abdel-Maksoud Mostafa A, Maodaa Saleh, Allam Ahmed A, Al-Basher Gadh I, Mahmoud Ayman M
1 Zoology Department, College of Science, King Saud University, Riyadh, Saudi Arabia.
2 Zoology Department, Faculty of Science, Beni-Suef University, Beni Suef, Egypt.
Toxicol Ind Health. 2018 Oct;34(10):679-692. doi: 10.1177/0748233718781290. Epub 2018 Jul 13.
Exposure to heavy metal-containing dust arising from stone quarrying may cause severe health problems. The aim of this study was to evaluate the impact of stone quarrying in Riyadh (Saudi Arabia) on the Libyan jird Meriones libycus. Soil samples and jirds were collected from four sites located at different distances from the quarrying area. Soil from the first (500 m away from the quarry) and second (1800 m away) sites showed a significant increase in cadmium (Cd), lead (Pb), nickel (Ni), and vanadium (V) when compared with the reference site (38,000 m away). Jirds at these sites exhibited significant increases in liver, kidney, lung, and fur levels of Cd, Pb, Ni, and V. Serum transaminases, creatinine, and malondialdehyde (MDA) levels were significantly increased in jirds, whereas reduced glutathione (GSH) levels decreased. Liver, kidney, and lung tissues of jirds, collected from the first and second sites, showed significantly increased MDA and decreased GSH levels. Additionally, animals at both sites showed altered hematological parameters and several histopathological changes in their liver, kidney, and lung. Soil and animals at the third site (7300 m away) showed no significant changes. Thus, our study showed the impact and hazardous effects of quarrying on the liver, kidney, lung, and hemogram of M. libycus. These findings can provide scientific evaluation for studying the impact of quarrying on the workers and communities living close to the studied area.
接触采石场产生的含重金属粉尘可能会导致严重的健康问题。本研究的目的是评估利雅得（沙特阿拉伯）的采石场对利比亚沙鼠（Meriones libycus）的影响。从距离采石场不同距离的四个地点采集了土壤样本和沙鼠。与参考地点（距离38000米）相比，第一个地点（距离采石场500米）和第二个地点（距离1800米）的土壤中镉（Cd）、铅（Pb）、镍（Ni）和钒（V）含量显著增加。这些地点的沙鼠肝脏、肾脏、肺和皮毛中的Cd、Pb、Ni和V含量显著增加。沙鼠的血清转氨酶、肌酐和丙二醛（MDA）水平显著升高，而还原型谷胱甘肽（GSH）水平降低。从第一个和第二个地点采集的沙鼠肝脏、肾脏和肺组织显示MDA水平显著升高，GSH水平降低。此外，两个地点的动物血液学参数均发生改变，肝脏、肾脏和肺出现了一些组织病理学变化。第三个地点（距离7300米）的土壤和动物没有显著变化。因此，我们的研究显示了采石场对利比亚沙鼠肝脏、肾脏、肺和血常规的影响及危害。这些发现可为研究采石场对靠近研究区域的工人和社区的影响提供科学评估。
