Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Biology, Faculty of Science, Chiang Mai University, 239 Huay Kaew Rd., Chiang Mai 50200, Thailand.
Molecules. 2018 Jul 2;23(7):1600. doi: 10.3390/molecules23071600.
Phytochemical investigations of the leaves and stems of led to the isolation of a new benzophenone -glucoside named pseuduvarioside (), together with six known compounds including (-)-guaiol (), (+)-isocorydine (), cyathocaline (), isoursoline (), --coumaroyltyramine (), and --feruloyltyramine (). Their structures were characterized by NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for inhibitory activity against the enzyme α-glucosidase. --coumaroyltyramine and --feruloyltyramine showed higher activity than the drug acarbose. Kinetic studies revealed that both tyramine-derived amides were uncompetitive inhibitors of the enzyme.
对 led 的叶和茎的植物化学研究导致了一个新的苯甲酮 - 葡萄糖苷的分离，名为 pseuduvarioside ()，以及包括 (-)-guaiol (), (+)-isocorydine (), cyathocaline (), isoursoline (), --coumaroyltyramine (), 和 --feruloyltyramine ()在内的六种已知化合物。它们的结构通过 NMR 光谱和质谱进行了表征。所有分离物都针对α-葡萄糖苷酶的抑制活性进行了评估。--coumaroyltyramine 和 --feruloyltyramine 比药物阿卡波糖显示出更高的活性。动力学研究表明，两种酪胺衍生酰胺都是该酶的非竞争性抑制剂。
