Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Department of Pharmacognosy, University of Pharmacy, Yangon 11031, Myanmar.
Molecules. 2020 Aug 2;25(15):3533. doi: 10.3390/molecules25153533.
The phytochemical investigation of resulted in the isolation of two new and five known compounds. The new compounds were characterized as undescribed 8-oxoprotoberberine alkaloids and named huberanthines A and B, whereas the known compounds were identified as allantoin, oxylopinine, --feruloyl tyramine, coumaroyl tyramine, and mangiferin. The structure determination was accomplished by spectroscopic methods. To evaluate therapeutic potential in diabetes and Parkinson's disease, the isolates were subjected to assays for their α-glucosidase inhibitory activity, cellular glucose uptake stimulatory activity, and protective activity against neurotoxicity induced by 6-hydroxydopamine (6-OHDA). The results suggested that mangiferin was the most promising lead compound, demonstrating significant activity in all the test systems.
对 进行的植物化学研究导致分离出两种新的和五种已知的化合物。新化合物被鉴定为未描述的 8-氧代原小檗碱生物碱，并分别命名为 huberanthines A 和 B，而已知化合物则被鉴定为尿囊素、氧化小檗碱、--阿魏酰酪胺、咖啡酰酪胺和芒果苷。结构测定通过光谱方法完成。为了评估在糖尿病和帕金森病中的治疗潜力，对分离出的化合物进行了α-葡萄糖苷酶抑制活性、细胞葡萄糖摄取刺激活性以及对 6-羟多巴胺（6-OHDA）诱导的神经毒性的保护活性测定。结果表明，芒果苷是最有前途的先导化合物，在所有测试系统中均显示出显著的活性。
