一种来自越南暗罗（Pseuduvaria indochinensis Merr.）的新型苯并吡喃衍生物

A new benzopyran derivative from Pseuduvaria indochinensis Merr.

作者信息

Zhao Cai-Gui, Yao Ming-Jun, Yang Jin-Wei, Chai Ya-Lin, Sun Xiao-Dong, Yuan Cheng-Shan

机构信息

a State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000 , P.R. China.

出版信息

Nat Prod Res. 2014;28(3):169-73. doi: 10.1080/14786419.2013.863197. Epub 2013 Dec 4.

DOI:10.1080/14786419.2013.863197

PMID:24304237

Abstract

From the twigs and leaves of Pseuduvaria indochinensis Merr., a new benzopyran derivative, pseudindochin (1), was isolated together with three known compounds, oligandrol (2), (6E,10E)-isopolycerasoidol (3) and polycerasoidol (4). The structure of compound 1 was elucidated on the basis of extensive spectroscopic data interpretation, including 1D, 2D NMR, HR-ESI-MS, UV and IR. Moreover, compounds 1-4 were evaluated in vitro for their cytotoxic activities against HL-60 and SMMC-7721 cell lines, but these compounds were essentially non-cytotoxic (IC50>30 μg/mL).

摘要

从越南紫玉盘（Pseuduvaria indochinensis Merr.）的枝叶中，分离得到了一种新的苯并吡喃衍生物——伪印支素（1），以及三种已知化合物——少花紫玉盘醇（2）、(6E,10E)-异多花紫玉盘醇（3）和多花紫玉盘醇（4）。通过广泛的光谱数据分析，包括一维、二维核磁共振、高分辨电喷雾电离质谱、紫外和红外光谱，阐明了化合物1的结构。此外，对化合物1 - 4进行了体外抗HL-60和SMMC-7721细胞系的细胞毒活性评价，但这些化合物基本无细胞毒性（IC50>30 μg/mL）。