Pazos A, Probst A, Palacios J M
Brain Res. 1985 Dec 9;358(1-2):324-8. doi: 10.1016/0006-8993(85)90977-1.
The distribution and characteristics of beta-adrenoceptors in postmortem human brain was studied using quantitative autoradiographic techniques. 125I-Cyanopindolol was used as a ligand. High densities of beta-adrenoceptors were found in the caudate, putamen, different cortical areas and layers and the hippocampal formation. Low densities were present in other areas such as the thalamus, hypothalamus, midbrain and cerebellar cortex. Specific beta 1 and beta 2 antagonists were used to visualize and quantify separately the two subtypes of beta-adrenoceptors. Computer analysis of the competition curves obtained revealed that the putamen was enriched in beta 1 sites while the cerebellum contained predominantly beta 2 adrenoceptors. The regional distribution of beta-adrenoceptor subtypes was found to be similar to that seen in the rat brain.
采用定量放射自显影技术研究了人死后大脑中β-肾上腺素能受体的分布及特性。以125I-氰吲哚洛尔作为配体。在尾状核、壳核、不同的皮质区域和层以及海马结构中发现了高密度的β-肾上腺素能受体。在丘脑、下丘脑、中脑和小脑皮质等其他区域则存在低密度。使用特异性的β1和β2拮抗剂分别对β-肾上腺素能受体的两种亚型进行可视化和定量分析。对所得竞争曲线的计算机分析显示，壳核富含β1位点，而小脑主要含有β2肾上腺素能受体。发现β-肾上腺素能受体亚型的区域分布与大鼠脑中所见相似。
