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用于肿瘤的靶向四重模态（磁共振成像/计算机断层扫描/光声成像）及光热治疗的磁金诊疗纳米制剂。

Magnetic-gold theranostic nanoagent used for targeting quad modalities & -MRI/CT/PA imaging and photothermal therapy of tumours.

作者信息

Liu Jinlei, Wang Dan, Wang Guannan

机构信息

The First Affiliated Hospital of Jinzhou Medical University Jinzhou 121001 China

Basic Medical College, Beihua University Jilin City 132013 China.

出版信息

RSC Adv. 2021 May 21;11(30):18440-18447. doi: 10.1039/d1ra02041b. eCollection 2021 May 19.

DOI:10.1039/d1ra02041b
PMID:35480951
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9033428/
Abstract

We describe a new type of ultra-small magneto-gold nanoparticle (MGN) with folic acid (FA)-based tumour targeting and multimodal imaging-guided photothermal therapy (PTT) properties that can be used as a theranostic nanoagent. The nanoagent integrates these MGNs-FA with surface modifications, and as expected, is monodisperse, and exhibits small size, strong NIR absorption, photothermal stability, good relaxivity and X-ray absorption coefficient, tumour targeting and excellent biocompatibility. Based on these properties, the nanoagent was successfully tested, both as a photothermal agent for high PTT efficacy and as a multimodality contrast agent for - & -MRI/CT/PA imaging and . Notably, the results of theranostic experiments with these MGNs-FA showed that they are highly effective and safe, indicating that they are efficient and promising theranostic agents that permit comprehensive imaging for diagnosis and therapy.

摘要

我们描述了一种新型的超小磁金纳米颗粒（MGN），其具有基于叶酸（FA）的肿瘤靶向性以及多模态成像引导的光热疗法（PTT）特性，可作为一种诊疗纳米剂。该纳米剂将这些MGN-FA与表面修饰相结合，不出所料，它具有单分散性，尺寸小、近红外吸收强、光热稳定性好、弛豫率高以及X射线吸收系数高，具有肿瘤靶向性和出色的生物相容性。基于这些特性，该纳米剂作为具有高PTT疗效的光热剂以及用于T1-和T2-MRI/CT/PA成像的多模态造影剂均成功通过了测试。值得注意的是，这些MGN-FA的诊疗实验结果表明它们高效且安全，这表明它们是高效且有前景的诊疗剂，能够实现用于诊断和治疗的全面成像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/c0c018925ef2/d1ra02041b-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/b5101e0d1b4e/d1ra02041b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/400aa12c4cac/d1ra02041b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/6afffb94185e/d1ra02041b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/b0a5dc6dee07/d1ra02041b-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/2cb26f322a04/d1ra02041b-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/72ede5e5f0e3/d1ra02041b-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/de6defd29cde/d1ra02041b-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/c0c018925ef2/d1ra02041b-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/b5101e0d1b4e/d1ra02041b-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/400aa12c4cac/d1ra02041b-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/6afffb94185e/d1ra02041b-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/b0a5dc6dee07/d1ra02041b-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/2cb26f322a04/d1ra02041b-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/72ede5e5f0e3/d1ra02041b-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/de6defd29cde/d1ra02041b-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbcc/9033428/c0c018925ef2/d1ra02041b-f8.jpg

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