Music and Health Science Research Center, Faculty of Music and Collaborative Programs in Neuroscience, University of Toronto, 90 Wellesley Street West, Toronto, Ontario M5S 1C5, Canada.
Music and Health Science Research Center, Faculty of Music and Collaborative Programs in Neuroscience, University of Toronto, 90 Wellesley Street West, Toronto, Ontario M5S 1C5, Canada.
Ageing Res Rev. 2018 Nov;47:133-139. doi: 10.1016/j.arr.2018.07.001. Epub 2018 Jul 10.
Parkinson's disease (PD) is characterized primarily by a dysfunctional basal ganglia (BG) system, producing motor and non-motor symptoms. A significant number of studies have demonstrated that rhythmic auditory stimulation can improve gait and other motor behaviors in PD that are not well managed by the conventional therapy. As music, being highly complex stimulus, can modulate brain activity/function in distributed areas of brain, the therapeutic properties of music potentially extend to alleviate non-motor symptoms of PD. Despite the clinical, behavioral evidence and promises of rhythm and music based interventions, the neural substrates underlying the effectiveness are poorly understood. The goal of this review is to appraise the current state of knowledge in order to direct further neuroimaging studies that help to determine the therapeutic effects of rhythm and music based interventions for motor and non-motor symptoms of PD.
帕金森病（PD）的主要特征是基底神经节（BG）系统功能失调，产生运动和非运动症状。大量研究表明，节奏性听觉刺激可以改善 PD 患者常规治疗效果不佳的步态和其他运动行为。由于音乐是一种高度复杂的刺激，可以调节大脑活动/功能在大脑的分布区域，音乐的治疗特性可能延伸到缓解 PD 的非运动症状。尽管有临床、行为证据和基于节奏和音乐的干预措施的承诺，但对其有效性的神经基础知之甚少。本综述的目的是评估当前的知识状况，以指导进一步的神经影像学研究，帮助确定基于节奏和音乐的干预措施对 PD 的运动和非运动症状的治疗效果。
