• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Local drug delivery to the inner ear: Principles, practice, and future challenges.

作者信息

Plontke Stefan K, Salt Alec N

机构信息

Department of Otorhinolaryngology, Head and Neck Surgery, Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.

Department of Otolaryngology, Head and Neck Surgery, Washington University in St. Louis, St. Louis, USA.

出版信息

Hear Res. 2018 Oct;368:1-2. doi: 10.1016/j.heares.2018.06.018. Epub 2018 Jun 28.

DOI:10.1016/j.heares.2018.06.018
PMID:30006112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6489445/
Abstract
摘要

相似文献

1
Local drug delivery to the inner ear: Principles, practice, and future challenges.内耳局部药物递送:原理、实践与未来挑战。
Hear Res. 2018 Oct;368:1-2. doi: 10.1016/j.heares.2018.06.018. Epub 2018 Jun 28.
2
Diseases and targets for local drug delivery to the inner ear.内耳局部给药的疾病与靶点
Hear Res. 2018 Oct;368:3-9. doi: 10.1016/j.heares.2018.05.005. Epub 2018 May 11.
3
Clinical trials for inner ear drugs: Design and execution challenges.内耳药物的临床试验:设计和执行挑战。
Hear Res. 2018 Oct;368:123-126. doi: 10.1016/j.heares.2018.03.020. Epub 2018 Mar 22.
4
Pharmacokinetic principles in the inner ear: Influence of drug properties on intratympanic applications.内耳的药代动力学原理:药物性质对鼓室内应用的影响。
Hear Res. 2018 Oct;368:28-40. doi: 10.1016/j.heares.2018.03.002. Epub 2018 Mar 11.
5
Controlled drug release to the inner ear: Concepts, materials, mechanisms, and performance.内耳的药物控释:概念、材料、机制和性能。
Hear Res. 2018 Oct;368:49-66. doi: 10.1016/j.heares.2018.03.006. Epub 2018 Mar 9.
6
Anatomical basis of drug delivery to the inner ear.内耳药物递送的解剖学基础。
Hear Res. 2018 Oct;368:10-27. doi: 10.1016/j.heares.2018.06.017. Epub 2018 Jun 27.
7
Outlook and future of inner ear therapy.内耳治疗的前景展望。
Hear Res. 2018 Oct;368:127-135. doi: 10.1016/j.heares.2018.05.009. Epub 2018 May 17.
8
Animal model studies yield translational solutions for cochlear drug delivery.动物模型研究为耳蜗药物输送提供转化解决方案。
Hear Res. 2018 Oct;368:67-74. doi: 10.1016/j.heares.2018.05.002. Epub 2018 May 5.
9
Introduction: Pathology of the inner ear.引言:内耳病理学
Hear Res. 2011 Nov;281(1-2):1-2. doi: 10.1016/j.heares.2011.10.005.
10
Recent advances in therapeutics and drug delivery for the treatment of inner ear diseases: a patent review (2011-2015).内耳疾病治疗的治疗学与药物递送的最新进展:专利综述(2011 - 2015年)
Expert Opin Ther Pat. 2017 Feb;27(2):191-202. doi: 10.1080/13543776.2017.1252751. Epub 2016 Nov 18.

引用本文的文献

1
Assessment of Safety, Tolerability, Pharmacokinetics, and Volume-Dependent Conductive Hearing Loss in Healthy Volunteers: First-in-Human, Open-Label, Placebo-Controlled Study of a Single Intratympanic Injection of AC102.健康志愿者中AC102单次鼓室内注射的安全性、耐受性、药代动力学及容量依赖性传导性听力损失评估:首次人体开放标签、安慰剂对照研究
Otol Neurotol. 2025 Sep 1;46(8):884-894. doi: 10.1097/MAO.0000000000004568.
2
Virally mediated enhancement of efferent inhibition reduces acoustic trauma in wild-type murine cochleas.病毒介导的传出抑制增强可减轻野生型小鼠耳蜗的声损伤。
Mol Ther Methods Clin Dev. 2025 Mar 21;33(2):101455. doi: 10.1016/j.omtm.2025.101455. eCollection 2025 Jun 12.
3

本文引用的文献

1
Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration.胚胎干细胞源性视网膜色素上皮贴片中年龄相关性黄斑变性的 1 期临床研究。
Nat Biotechnol. 2018 Apr;36(4):328-337. doi: 10.1038/nbt.4114. Epub 2018 Mar 19.
2
Dementia prevention, intervention, and care.痴呆症的预防、干预与护理。
Lancet. 2017 Dec 16;390(10113):2673-2734. doi: 10.1016/S0140-6736(17)31363-6. Epub 2017 Jul 20.
3
Intracochlear drug delivery in combination with cochlear implants : Current aspects.
Virally-Mediated Enhancement of Efferent Inhibition Reduces Acoustic Trauma in Wild Type Murine Cochleas.
病毒介导的传出抑制增强可减轻野生型小鼠耳蜗的听觉创伤。
bioRxiv. 2024 Sep 15:2024.09.12.612688. doi: 10.1101/2024.09.12.612688.
4
Ototoxicity: a high risk to auditory function that needs to be monitored in drug development.耳毒性:对听觉功能有高风险,在药物研发中需要进行监测。
Front Mol Neurosci. 2024 May 2;17:1379743. doi: 10.3389/fnmol.2024.1379743. eCollection 2024.
5
[Role of intratympanic glucocorticoid treatment in sudden hearing loss].鼓室内糖皮质激素治疗在突发性听力损失中的作用
HNO. 2024 Apr;72(4):291-302. doi: 10.1007/s00106-024-01424-z. Epub 2024 Feb 13.
6
CochleRob: Parallel-Serial Robot to Position a Magnetic Actuator around a Patient's Head for Intracochlear Microrobot Navigation.CochleRob:一种用于将磁驱动器放置在患者头部周围的串并混联机器人,以实现耳蜗内微机器人导航。
Sensors (Basel). 2023 Mar 9;23(6):2973. doi: 10.3390/s23062973.
7
Optical Coherence Tomography-Based Atlas of the Human Cochlear Hook Region.基于光学相干断层扫描技术的人类耳蜗钩区图谱。
J Clin Med. 2022 Dec 28;12(1):238. doi: 10.3390/jcm12010238.
8
Unlocking the human inner ear for therapeutic intervention.为治疗干预解锁人类内耳。
Sci Rep. 2022 Nov 8;12(1):18508. doi: 10.1038/s41598-022-22203-2.
9
The Clinical Effect of Steroids for Hearing Preservation in Cochlear Implantation: Conclusions Based on Three Cochlear Implant Systems and Two Administration Regimes.类固醇在人工耳蜗植入中听力保留的临床效果:基于三种人工耳蜗系统和两种给药方案的结论
Pharmaceuticals (Basel). 2022 Sep 22;15(10):1176. doi: 10.3390/ph15101176.
10
AON-based degradation of c.151C>T mutant transcripts associated with dominantly inherited hearing impairment DFNA9.基于反义寡核苷酸的与显性遗传性听力损失DFNA9相关的c.151C>T突变转录本的降解
Mol Ther Nucleic Acids. 2021 Mar 1;24:274-283. doi: 10.1016/j.omtn.2021.02.033. eCollection 2021 Jun 4.
人工耳蜗联合鼓室内给药:现状
HNO. 2017 Jan;65(Suppl 1):19-28. doi: 10.1007/s00106-016-0285-9.
4
Restoration of auditory evoked responses by human ES-cell-derived otic progenitors.人胚胎干细胞来源的耳前体细胞对听觉诱发电位的修复作用。
Nature. 2012 Oct 11;490(7419):278-82. doi: 10.1038/nature11415. Epub 2012 Sep 12.
5
Principles of local drug delivery to the inner ear.内耳局部给药的原则。
Audiol Neurootol. 2009;14(6):350-60. doi: 10.1159/000241892. Epub 2009 Nov 16.
6
Gentamicin and other ototoxic antibiotics for the transtympanic treatment of Menière's disease.庆大霉素及其他耳毒性抗生素用于梅尼埃病的鼓室注射治疗。
Arch Otorhinolaryngol. 1989;246(5):269-70. doi: 10.1007/BF00463571.