Department of Pharmacy, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, PR China.
Department of Clinical Pharmacy, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, PR China.
Clin Chim Acta. 2018 Oct;485:282-287. doi: 10.1016/j.cca.2018.07.010. Epub 2018 Jul 10.
Serum cystatin C (CysC) measurement is regarded as a simple and practical alternative to measure residual renal function for dialysis patients. Recent studies have shown that CysC has better diagnostic accuracy or at least equivalence to creatinine in predicting the early stages of renal damage, and is closely related to clinical outcomes of dialysis patients. Thus, the applicability of CysC-derived equations in patients undergoing dialysis should be paid attention. Here, we review the role of CysC in diagnosis, renal function evaluation, and prognosis outcomes for dialysis patients, so as to provide them with useful suggestions on evaluating renal function and predicting adverse outcomes in clinical practice.
血清胱抑素 C（CysC）的测定被认为是一种简单实用的替代方法，可用于测量透析患者的残余肾功能。最近的研究表明，CysC 在预测早期肾损伤方面具有更好的诊断准确性，或者至少与肌酐相当，并且与透析患者的临床结局密切相关。因此，应该注意 CysC 衍生方程在接受透析治疗的患者中的适用性。在这里，我们回顾了 CysC 在诊断、肾功能评估和透析患者预后结局中的作用，以便为临床实践中评估肾功能和预测不良结局提供有用的建议。
