Sauvalle Marcel, Alvo Andrés
Department of Otorhinolaryngology, Hospital Clínico Universidad de Chile, Santos Dumont 999, Independencia, Santiago, Chile.
Eur Arch Otorhinolaryngol. 2018 Sep;275(9):2403-2406. doi: 10.1007/s00405-018-5060-y. Epub 2018 Jul 13.
The respiratory epithelium is mainly constituted by caliciform (produces mucus, responsible of keeping moisture and trapping particles) and ciliated cells (transports mucus into the pharynx, by the movement of multiple cilia). For centuries, nasal lavages have been used for different rhinosinusal conditions. Some studies suggest not only a direct effect on the mobilisation of secretions, but also an improvement in mucociliary clearance rates. To our knowledge, the impact of temperature in nasal lavages has been scarcely studied.
METHODOLOGY/PRINCIPAL: We used the saccharin test-applying it in the inferior turbinate and timing the detection of its taste-, to estimate mucociliary clearance rates before and after nasal lavages with saline solution at room (20 °C) or body (37 °C) temperatures.
78 healthy subjects were studied, with a mean saccharin test time of 13.88 min. Then, a nasal lavage was performed, half with 20 °C saline and the other with 37 °C. In both, times improved from baseline (from 13.66 to 11.59 and 14.06 to 9.4 min, respectively) with p values < 0.05.
Nasal lavages with saline solution improve mucociliary clearance as measured by saccharin test. Temperature seems to matter, which should be taken into account when indicating nasal lavages to our patients.
呼吸道上皮主要由杯状细胞（产生黏液，负责保持湿润并捕获颗粒）和纤毛细胞（通过多个纤毛的运动将黏液输送到咽部）组成。几个世纪以来，鼻腔灌洗一直用于治疗各种鼻-鼻窦疾病。一些研究表明，鼻腔灌洗不仅对分泌物的排出有直接作用，还能提高黏液纤毛清除率。据我们所知，很少有研究探讨鼻腔灌洗温度的影响。
方法/原理：我们采用糖精试验——将其应用于下鼻甲并记录其味道检测时间，以评估在室温（20°C）或体温（37°C）的生理盐水进行鼻腔灌洗前后的黏液纤毛清除率。
对78名健康受试者进行了研究，糖精试验平均时间为13.88分钟。然后进行鼻腔灌洗，一半用20°C的生理盐水，另一半用37°C的生理盐水。两种情况下，时间均较基线有所改善（分别从13.66分钟降至11.59分钟和从14.06分钟降至9.4分钟），p值<0.05。
用糖精试验测量，生理盐水鼻腔灌洗可改善黏液纤毛清除率。温度似乎有影响，在向患者说明鼻腔灌洗时应予以考虑。
