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生命的物理密码之译

Translating the Physical Code of Life.

机构信息

Biophysics Program, Stanford University, Stanford, CA 94305, USA.

Biophysics Program, Stanford University, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.

出版信息

Cell. 2018 Jul 12;174(2):253-255. doi: 10.1016/j.cell.2018.06.050.

Abstract

The cytoplasm is a highly crowded and complex environment, and the regulation of its physical properties has only recently begun to be revealed. In this issue of Cell, Delarue et al. demonstrate that the control of ribosome concentration through mTORC1 sets limits on the diffusion of large particles and controls phase separation in eukaryotic cells.

摘要

细胞质是一个高度拥挤和复杂的环境,其物理性质的调节直到最近才开始被揭示。在本期《细胞》杂志上,Delarue 等人证明了通过 mTORC1 控制核糖体浓度限制了大颗粒的扩散,并控制了真核细胞的液-液相分离。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f958/6586463/f191b1d85c23/nihms-1036068-f0001.jpg

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本文引用的文献

2
Protein Phase Separation: A New Phase in Cell Biology.蛋白质液-液相分离:细胞生物学的一个新领域。
Trends Cell Biol. 2018 Jun;28(6):420-435. doi: 10.1016/j.tcb.2018.02.004. Epub 2018 Mar 27.
3
Microorganisms maintain crowding homeostasis.微生物维持拥挤平衡。
Nat Rev Microbiol. 2017 May;15(5):309-318. doi: 10.1038/nrmicro.2017.17. Epub 2017 Mar 27.
4
Compositional Control of Phase-Separated Cellular Bodies.相分离细胞体的组成控制
Cell. 2016 Jul 28;166(3):651-663. doi: 10.1016/j.cell.2016.06.010. Epub 2016 Jun 30.
7
Intracellular transport by active diffusion.通过主动扩散进行的细胞内运输。
Trends Cell Biol. 2009 Sep;19(9):423-7. doi: 10.1016/j.tcb.2009.04.004. Epub 2009 Aug 21.
9
Probing the structure of cytoplasm.探究细胞质的结构。
J Cell Biol. 1986 Jun;102(6):2015-22. doi: 10.1083/jcb.102.6.2015.

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