Biophysics Program, Stanford University, Stanford, CA 94305, USA.
Biophysics Program, Stanford University, Stanford, CA 94305, USA; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA.
Cell. 2018 Jul 12;174(2):253-255. doi: 10.1016/j.cell.2018.06.050.
The cytoplasm is a highly crowded and complex environment, and the regulation of its physical properties has only recently begun to be revealed. In this issue of Cell, Delarue et al. demonstrate that the control of ribosome concentration through mTORC1 sets limits on the diffusion of large particles and controls phase separation in eukaryotic cells.
细胞质是一个高度拥挤和复杂的环境,其物理性质的调节直到最近才开始被揭示。在本期《细胞》杂志上,Delarue 等人证明了通过 mTORC1 控制核糖体浓度限制了大颗粒的扩散,并控制了真核细胞的液-液相分离。