Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
J Pediatr. 2018 Oct;201:27-33.e4. doi: 10.1016/j.jpeds.2018.06.004. Epub 2018 Jul 13.
To examine whether feeding patterns from birth to age 6 months modify the association between birth weight and weight at 7-12 months of age.
Longitudinal mixed models were used to examine feeding trajectories across categories of birth weight and weight at 7-12 months of age in 1799 mother-infant dyads enrolled in the Infant Feeding Practices Study II. The percentage of breast milk received and the average daily formula consumption were calculated from birth to 6 months of age. Birth weights were classified as high (≥4000 g) and normal (≥2500 g and <4000 g). Weights at 7-12 months of age were categorized as high (z score >1) or normal (z score ≤1). A secondary analysis was performed using categories defined by birth weight adjusted for gestational age percentiles (>90% and 10th-90th percentile).
High birth weight (HBW) infants with high weights at 7-12 months of age demonstrated a rapid decline in the percentage of breast milk feedings compared with HBW infants with normal weights at 7-12 months of age. Normal birth weight infants with high weights at 7-12 months of age received a lower percentage of breast milk and had greater absolute intakes of formula than those with normal weights at 7-12 months of age; these associations did not vary over time. Results were similar when infants were categorized by birth weight percentiles.
A lower proportion of breast milk feedings was associated with excess weight at 7-12 months of age in HBW infants. These findings suggest an initial target for obesity prevention programs focusing on the first 6 months after birth.
研究从出生到 6 个月的喂养模式是否会改变出生体重与 7-12 个月体重之间的关系。
采用纵向混合模型，在婴儿喂养实践研究 II 中纳入的 1799 对母婴对中，根据出生体重和 7-12 个月体重的类别，检查了喂养轨迹。从出生到 6 个月，计算了母乳的百分比和平均每日配方奶的消耗量。出生体重分为高（≥4000g）和正常（≥2500g 和<4000g）。7-12 个月的体重分为高（z 评分>1）或正常（z 评分≤1）。使用按胎龄百分位（>90%和 10-90%）调整的出生体重类别进行了二次分析。
与 7-12 个月体重正常的高出生体重（HBW）婴儿相比，7-12 个月体重高的 HBW 婴儿的母乳喂养百分比迅速下降。7-12 个月体重高的正常出生体重婴儿的母乳喂养百分比较低，7-12 个月体重正常的婴儿的配方奶摄入量绝对值较高；这些关联随着时间的推移而没有变化。当婴儿按出生体重百分位分类时，结果相似。
与 7-12 个月体重正常的 HBW 婴儿相比，母乳喂养比例较低与 7-12 个月时超重有关。这些发现表明，肥胖预防计划的初始目标应侧重于出生后前 6 个月。
