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Is (S)-norketamine an alternative antidepressant for esketamine?

作者信息

Hashimoto Kenji, Yang Chun

机构信息

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chiba, 260-8670, Japan.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

出版信息

Eur Arch Psychiatry Clin Neurosci. 2019 Oct;269(7):867-868. doi: 10.1007/s00406-018-0922-2. Epub 2018 Jul 14.

DOI:10.1007/s00406-018-0922-2
PMID:30008119
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6739277/
Abstract
摘要

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2
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Rapid antidepressant effects and abuse liability of ketamine.氯胺酮的快速抗抑郁作用及滥用倾向
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US Food and Drug Administration approval of esketamine and brexanolone.美国食品药品监督管理局对艾氯胺酮和布瑞诺龙的批准。
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Esketamine for treatment‑resistant depression: A review of clinical evidence (Review).艾氯胺酮治疗难治性抑郁症：临床证据综述（综述）
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The molecular pathophysiology of depression and the new therapeutics.抑郁症的分子病理生理学与新疗法

本文引用的文献

1
AMPA Receptor Activation-Independent Antidepressant Actions of Ketamine Metabolite (S)-Norketamine.氯胺酮代谢产物（S）-去甲氯胺酮的 AMPA 受体激活非依赖性抗抑郁作用。
Biol Psychiatry. 2018 Oct 15;84(8):591-600. doi: 10.1016/j.biopsych.2018.05.007. Epub 2018 May 14.
2
Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study.鼻腔内使用艾司氯胺酮治疗有自杀风险的抑郁症和自杀意念患者快速减轻症状的疗效和安全性：一项双盲、随机、安慰剂对照研究的结果。
Am J Psychiatry. 2018 Jul 1;175(7):620-630. doi: 10.1176/appi.ajp.2018.17060720. Epub 2018 Apr 16.
3
MedComm (2020). 2022 Jul 21;3(3):e156. doi: 10.1002/mco2.156. eCollection 2022 Sep.
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Molecular mechanisms underlying the antidepressant actions of arketamine: beyond the NMDA receptor.亚胺培南抗抑郁作用的分子机制：超越 NMDA 受体。
Mol Psychiatry. 2022 Jan;27(1):559-573. doi: 10.1038/s41380-021-01121-1. Epub 2021 May 7.
5
Esketamine: new hope for the treatment of treatment-resistant depression? A narrative review.艾氯胺酮：治疗难治性抑郁症的新希望？一篇叙述性综述。
Ther Adv Drug Saf. 2020 Jul 23;11:2042098620937899. doi: 10.1177/2042098620937899. eCollection 2020.
6
Ketamine as an antidepressant: overview of its mechanisms of action and potential predictive biomarkers.氯胺酮作为一种抗抑郁药：其作用机制及潜在预测生物标志物概述。
Ther Adv Psychopharmacol. 2020 May 11;10:2045125320916657. doi: 10.1177/2045125320916657. eCollection 2020.
7
Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression.在一项针对难治性重度抑郁症的随机、安慰剂对照、交叉试验中，氯胺酮代谢物、临床反应和γ波功率
Neuropsychopharmacology. 2020 Jul;45(8):1398-1404. doi: 10.1038/s41386-020-0663-6. Epub 2020 Apr 6.
8
Esketamine: a glimmer of hope in treatment-resistant depression.依他佐辛：治疗抵抗性抑郁症的一线希望。
Eur Arch Psychiatry Clin Neurosci. 2021 Apr;271(3):417-429. doi: 10.1007/s00406-019-01084-z. Epub 2019 Nov 19.
9
Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites.氯胺酮对映异构体及其代谢物抗抑郁作用的分子和细胞机制。
Transl Psychiatry. 2019 Nov 7;9(1):280. doi: 10.1038/s41398-019-0624-1.
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Mood, psychomotor, and cognitive function in major depressive disorder: from biomarkers to rapid-acting antidepressants.重度抑郁症中的情绪、精神运动及认知功能：从生物标志物到速效抗抑郁药
Eur Arch Psychiatry Clin Neurosci. 2019 Oct;269(7):759-760. doi: 10.1007/s00406-019-01061-6.
Efficacy and Safety of Intranasal Esketamine Adjunctive to Oral Antidepressant Therapy in Treatment-Resistant Depression: A Randomized Clinical Trial.
鼻腔内依他佐辛辅助口服抗抑郁药治疗难治性抑郁症的疗效和安全性：一项随机临床试验。
JAMA Psychiatry. 2018 Feb 1;75(2):139-148. doi: 10.1001/jamapsychiatry.2017.3739.
4
Side-effects associated with ketamine use in depression: a systematic review.氯胺酮用于治疗抑郁症的副作用：一项系统评价
Lancet Psychiatry. 2018 Jan;5(1):65-78. doi: 10.1016/S2215-0366(17)30272-9. Epub 2017 Jul 27.
5
A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders.关于使用氯胺酮治疗心境障碍的共识声明。
JAMA Psychiatry. 2017 Apr 1;74(4):399-405. doi: 10.1001/jamapsychiatry.2017.0080.
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Letter to the Editor: R-ketamine: a rapid-onset and sustained antidepressant without risk of brain toxicity.致编辑的信：R-氯胺酮：一种起效迅速且持续作用的抗抑郁药，无脑毒性风险。
Psychol Med. 2016 Aug;46(11):2449-51. doi: 10.1017/S0033291716000969. Epub 2016 Jun 10.
7
Reduction of dopamine D receptor binding in the striatum after a single administration of esketamine, but not R-ketamine: a PET study in conscious monkeys.单次给予艾司氯胺酮后纹状体中多巴胺D受体结合减少，但R-氯胺酮无此作用：清醒猴子的正电子发射断层扫描研究
Eur Arch Psychiatry Clin Neurosci. 2017 Mar;267(2):173-176. doi: 10.1007/s00406-016-0692-7. Epub 2016 Apr 18.
8
Intravenous Esketamine in Adult Treatment-Resistant Depression: A Double-Blind, Double-Randomization, Placebo-Controlled Study.静脉用依他佐辛治疗成人治疗抵抗性抑郁症：一项双盲、双随机、安慰剂对照研究。
Biol Psychiatry. 2016 Sep 15;80(6):424-431. doi: 10.1016/j.biopsych.2015.10.018. Epub 2015 Nov 3.
9
R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects.R-氯胺酮：一种起效迅速且作用持久的抗抑郁药，无拟精神病性副作用。
Transl Psychiatry. 2015 Sep 1;5(9):e632. doi: 10.1038/tp.2015.136.