Deng Mengjie, Pan Yunzhi, Zhou Li, Chen Xudong, Liu Chang, Huang Xiaojun, Tao Haojuan, Pu Weidan, Wu Guowei, Hu Xinran, He Zhong, Xue Zhimin, Liu Zhening, Rosenheck Robert
Hunan Key Laboratory of Psychiatry and Mental Health, Department of Psychiatry, Second Xiangya Hospital of Central South University, China National Clinical Research Center on Mental Health Disorders, China National Technology Institute on Mental Disorders, Hunan Technology Institute of Psychiatry, Mental Health Institute of Central South University, Changsha, China.
Department of Psychiatry, First Affiliated Hospital of Jinan University, Guangzhou, China.
Front Psychiatry. 2018 Jun 29;9:279. doi: 10.3389/fpsyt.2018.00279. eCollection 2018.
This study compared adaptive resilience among patients with schizophrenia, bipolar disorder, and healthy controls, and examined the relationship of resilience to cognitive function. A sample of 81 patients diagnosed with schizophrenia, 34 with bipolar disorder, and 52 healthy controls completed the Connor-Davidson Resilience Scale (CD-RISC) and cognitive tests of verbal comprehension, executive functioning, and working memory. Paired comparison of diagnostic groups on CD-RISC and cognitive tests was conducted. Linear regression was used to identify the independent association of clinical diagnoses and neurocognition with resilience deficits. Both patient groups showed significantly lower CD-RISC scores and poorer cognitive function than healthy controls and the schizophrenia group scored lower than bipolar group on these measures as well. CD-RISC scores were positively correlated with all three cognitive measures in the entire sample but not within the diagnostic subgroups. Multiple regression analysis showed differences in CD-RISC between diagnostic groups were not mediated by differences in these three measures of neurocognition. Schizophrenia and bipolar disorder are associated with impairments in both resilience and cognitive function but the impairment in resilience appears to be independent of deficits in cognitive function measured here and may reflect unmeasured dimensions of cognitive function, other impairments or environmental factors.
本研究比较了精神分裂症患者、双相情感障碍患者和健康对照者的适应性恢复力，并考察了恢复力与认知功能之间的关系。81名被诊断为精神分裂症的患者、34名双相情感障碍患者和52名健康对照者完成了康纳-戴维森恢复力量表（CD-RISC）以及言语理解、执行功能和工作记忆的认知测试。对各诊断组在CD-RISC和认知测试上进行了配对比较。采用线性回归来确定临床诊断和神经认知与恢复力缺陷之间的独立关联。两个患者组的CD-RISC得分均显著低于健康对照者，且认知功能较差，在这些指标上精神分裂症组的得分也低于双相情感障碍组。在整个样本中，CD-RISC得分与所有三项认知指标呈正相关，但在诊断亚组中并非如此。多元回归分析表明，诊断组之间CD-RISC的差异并非由这三项神经认知指标的差异所介导。精神分裂症和双相情感障碍与恢复力和认知功能的损害均相关，但恢复力的损害似乎独立于此处所测量的认知功能缺陷，可能反映了认知功能未测量的维度、其他损害或环境因素。
