Chin Siok-Fong, Megat Mohd Azlan Putri Intan Hafizah, Mazlan Luqman, Neoh Hui-Min
1UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia.
2Department of Surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Cheras, Kuala Lumpur, Malaysia.
Gut Pathog. 2018 Jul 10;10:29. doi: 10.1186/s13099-018-0258-5. eCollection 2018.
Over the years, genetic profiling of the gut microbiome of patients with colorectal cancer (CRC) using genome sequencing has suggested over-representation of several bacterial taxa. However, little is known about the protein or metabolite secretions from the microbiota that could lead to CRC pathology. Proteomic studies on the role of microbial secretome in CRC are relatively rare. Here, we report the identification of proteins from found in the stool samples of both healthy individuals and patients with CRC. We found that distinctive sets of proteins were present exclusively and in high intensities in each group. Our finding may trigger a new interest in the role of gut mycobiota in carcinogenesis.
多年来，利用基因组测序对结直肠癌（CRC）患者的肠道微生物群进行基因谱分析表明，几种细菌类群的比例过高。然而，对于可能导致CRC病理的微生物群的蛋白质或代谢物分泌情况，我们却知之甚少。关于微生物分泌组在CRC中的作用的蛋白质组学研究相对较少。在这里，我们报告了在健康个体和CRC患者的粪便样本中发现的蛋白质的鉴定情况。我们发现，每组中都有独特的蛋白质组，它们仅以高强度存在。我们的发现可能会引发人们对肠道真菌群在致癌作用中的作用产生新的兴趣。
