Gamal Ahmed, Elshaer Mohammed, Alabdely Mayyadah, Kadry Ahmed, McCormick Thomas S, Ghannoum Mahmoud
Department of Dermatology, Case Western Reserve University, Cleveland, OH 44106, USA.
Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Cancers (Basel). 2022 Jun 10;14(12):2875. doi: 10.3390/cancers14122875.
Cancer is among the leading causes of death globally. Despite advances in cancer research, a full understanding of the exact cause has not been established. Recent data have shown that the microbiome has an important relationship with cancer on various levels, including cancer pathogenesis, diagnosis and prognosis, and treatment. Since most studies have focused only on the role of bacteria in this process, in this article we review the role of fungi-another important group of the microbiome, the totality of which is referred to as the "mycobiome"-in the development of cancer and how it can impact responses to anticancer medications. Furthermore, we provide recent evidence that shows how the different microbial communities interact and affect each other at gastrointestinal and non-gastrointestinal sites, including the skin, thereby emphasizing the importance of investigating the microbiome beyond bacteria.
癌症是全球主要死因之一。尽管癌症研究取得了进展，但尚未完全明确其确切病因。近期数据表明，微生物群在多个层面与癌症存在重要关联，包括癌症的发病机制、诊断与预后以及治疗。由于大多数研究仅关注细菌在此过程中的作用，本文将综述真菌（微生物群的另一个重要类别，其整体被称为“真菌群”）在癌症发生发展中的作用，以及它如何影响对抗癌药物的反应。此外，我们还提供了最新证据，展示了不同微生物群落如何在胃肠道和非胃肠道部位（包括皮肤）相互作用并相互影响，从而强调了超越细菌研究微生物群的重要性。
