Department Public Health Sciences, Penn State College Medicine, Hershey, USA.
Department of Epidemiology of Aging, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
Nutr J. 2023 Nov 22;22(1):62. doi: 10.1186/s12937-023-00887-0.
Prior study reported that mushroom consumption was associated with a lower incidence of hyperuricemia, but there is limited evidence on this association. We conducted a collaborative study to investigate the association between mushroom intake and hyperuricemia in middle-aged and older populations.
We used data from the National Health and Nutrition Examination Survey (NHANES) in the U.S. (2007-2018) and the National Institute for Longevity Sciences-Longitudinal Study of Aging (NILS-LSA) in Japan (1997-2012). Consumption of mushroom (g/day) were measured by one- or two-day dietary recall in NHANES and by 3-day dietary records in the NILS-LSA. Hyperuricemia was defined using uric acid levels as > 420 μmol/L and > 350 μmol/L in NHANES for men and women, respectively; in the NILS-LSA, serum uric acid was repeatedly measured at baseline and follow-up surveys. Hyperuricemia was defined as uric acid levels > 416.4 μmol/L for men and ≥ 356.9 μmol/L for women. Logistic regression models in NHANES (cross-sectionally) and Generalized Estimation Equations in NILS-LSA (longitudinally) were performed.
A total of 5,778 NHANES participants (mean (SD) age: 53.2 (9.6) years) and 1,738 NILS-LSA (mean (SD) age: 53.5 (11.2) years) were included. Mushrooms were consumed by 5.7% of participants in NHANES and 81.2% in NILS-LSA. We did not observe a significant association between mushroom intakes and hyperuricemia in the NHANES men and women. However, in the NILS-LSA, compared to non-consumers, a higher mushroom intake was associated with a lower risk of incident hyperuricemia in men under 65 years old. The adjusted odds ratio (95% CI) for non-consumers, participants with middle, and the highest consumption of mushrooms were 1.00 (Ref.), 0.77 (0.44, 1.36), and 0.55 (0.31, 0.99), respectively (P-trend = 0.036). No association was found in women in NILS-LSA.
Mushroom consumption was associated with a lower risk of incident hyperuricemia in Japanese men.
先前的研究报告称，食用蘑菇与高尿酸血症的发病率较低有关，但关于这种关联的证据有限。我们进行了一项合作研究，调查了中年和老年人群中蘑菇摄入量与高尿酸血症之间的关系。
我们使用了来自美国国家健康和营养检查调查（NHANES）（2007-2018 年）和日本国家长寿科学研究所-老龄化纵向研究（NILS-LSA）（1997-2012 年）的数据。NHANES 中通过一日或两日的膳食回顾来测量蘑菇（g/天）的摄入量，而 NILS-LSA 中则通过 3 日的膳食记录来测量。高尿酸血症的定义是尿酸水平男性分别为>420 μmol/L 和>350 μmol/L；在 NILS-LSA 中，基线和随访调查时反复测量血清尿酸。男性高尿酸血症的定义为尿酸水平>416.4 μmol/L，女性高尿酸血症的定义为尿酸水平≥356.9 μmol/L。NHANES 中使用逻辑回归模型（横截面）和 NILS-LSA 中使用广义估计方程（纵向）进行分析。
共纳入 5778 名 NHANES 参与者（平均（SD）年龄：53.2（9.6）岁）和 1738 名 NILS-LSA 参与者（平均（SD）年龄：53.5（11.2）岁）。NHANES 中有 5.7%的参与者食用蘑菇，NILS-LSA 中有 81.2%的参与者食用蘑菇。我们没有观察到蘑菇摄入量与 NHANES 男性和女性高尿酸血症之间存在显著关联。然而，在 NILS-LSA 中，与非食用者相比，65 岁以下男性摄入更多的蘑菇与较低的新发高尿酸血症风险相关。非食用者、中量食用者和最高量食用者的校正比值比（95%CI）分别为 1.00（Ref.）、0.77（0.44，1.36）和 0.55（0.31，0.99）（P 趋势=0.036）。NILS-LSA 中的女性未发现关联。
蘑菇摄入与日本男性新发高尿酸血症的风险降低有关。
