食用蘑菇与高尿酸血症：来自日本国立长寿科学研究所-老龄化纵向研究和美国国家健康与营养调查（2007-2018 年）的结果。

Mushroom consumption and hyperuricemia: results from the National Institute for Longevity Sciences-Longitudinal Study of Aging and the National Health and Nutrition Examination Survey (2007-2018).

机构信息

Department Public Health Sciences, Penn State College Medicine, Hershey, USA.

Department of Epidemiology of Aging, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.

出版信息

Nutr J. 2023 Nov 22;22(1):62. doi: 10.1186/s12937-023-00887-0.

DOI:10.1186/s12937-023-00887-0

PMID:37990262

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10664361/

Abstract

BACKGROUND

Prior study reported that mushroom consumption was associated with a lower incidence of hyperuricemia, but there is limited evidence on this association. We conducted a collaborative study to investigate the association between mushroom intake and hyperuricemia in middle-aged and older populations.

METHODS

We used data from the National Health and Nutrition Examination Survey (NHANES) in the U.S. (2007-2018) and the National Institute for Longevity Sciences-Longitudinal Study of Aging (NILS-LSA) in Japan (1997-2012). Consumption of mushroom (g/day) were measured by one- or two-day dietary recall in NHANES and by 3-day dietary records in the NILS-LSA. Hyperuricemia was defined using uric acid levels as > 420 μmol/L and > 350 μmol/L in NHANES for men and women, respectively; in the NILS-LSA, serum uric acid was repeatedly measured at baseline and follow-up surveys. Hyperuricemia was defined as uric acid levels > 416.4 μmol/L for men and ≥ 356.9 μmol/L for women. Logistic regression models in NHANES (cross-sectionally) and Generalized Estimation Equations in NILS-LSA (longitudinally) were performed.

RESULTS

A total of 5,778 NHANES participants (mean (SD) age: 53.2 (9.6) years) and 1,738 NILS-LSA (mean (SD) age: 53.5 (11.2) years) were included. Mushrooms were consumed by 5.7% of participants in NHANES and 81.2% in NILS-LSA. We did not observe a significant association between mushroom intakes and hyperuricemia in the NHANES men and women. However, in the NILS-LSA, compared to non-consumers, a higher mushroom intake was associated with a lower risk of incident hyperuricemia in men under 65 years old. The adjusted odds ratio (95% CI) for non-consumers, participants with middle, and the highest consumption of mushrooms were 1.00 (Ref.), 0.77 (0.44, 1.36), and 0.55 (0.31, 0.99), respectively (P-trend = 0.036). No association was found in women in NILS-LSA.

CONCLUSIONS

Mushroom consumption was associated with a lower risk of incident hyperuricemia in Japanese men.

摘要

背景

先前的研究报告称，食用蘑菇与高尿酸血症的发病率较低有关，但关于这种关联的证据有限。我们进行了一项合作研究，调查了中年和老年人群中蘑菇摄入量与高尿酸血症之间的关系。

方法

我们使用了来自美国国家健康和营养检查调查（NHANES）（2007-2018 年）和日本国家长寿科学研究所-老龄化纵向研究（NILS-LSA）（1997-2012 年）的数据。NHANES 中通过一日或两日的膳食回顾来测量蘑菇（g/天）的摄入量，而 NILS-LSA 中则通过 3 日的膳食记录来测量。高尿酸血症的定义是尿酸水平男性分别为>420 μmol/L 和>350 μmol/L；在 NILS-LSA 中，基线和随访调查时反复测量血清尿酸。男性高尿酸血症的定义为尿酸水平>416.4 μmol/L，女性高尿酸血症的定义为尿酸水平≥356.9 μmol/L。NHANES 中使用逻辑回归模型（横截面）和 NILS-LSA 中使用广义估计方程（纵向）进行分析。

结果

共纳入 5778 名 NHANES 参与者（平均（SD）年龄：53.2（9.6）岁）和 1738 名 NILS-LSA 参与者（平均（SD）年龄：53.5（11.2）岁）。NHANES 中有 5.7%的参与者食用蘑菇，NILS-LSA 中有 81.2%的参与者食用蘑菇。我们没有观察到蘑菇摄入量与 NHANES 男性和女性高尿酸血症之间存在显著关联。然而，在 NILS-LSA 中，与非食用者相比，65 岁以下男性摄入更多的蘑菇与较低的新发高尿酸血症风险相关。非食用者、中量食用者和最高量食用者的校正比值比（95%CI）分别为 1.00（Ref.）、0.77（0.44，1.36）和 0.55（0.31，0.99）（P 趋势=0.036）。NILS-LSA 中的女性未发现关联。