a School of Public Health , Nanjing Medical University , Nanjing , China.
b Jiangsu Provincial Center for Disease Control and Prevention , Nanjing , China.
Infect Dis (Lond). 2018 Oct;50(10):728-735. doi: 10.1080/23744235.2018.1472805. Epub 2018 Jul 15.
Not all individuals with Influenza like illness (ILI) seek healthcare. Knowing the proportion that do is important to evaluate the actual burden and fatality rate of ILI-relevant diseases, such as seasonal influenza and human infection with avian influenza. A number of studies have investigated the healthcare seeking rate, but the results varied from 0.16 to 0.85. We conducted this analysis for better understanding the healthcare seeking rate for ILI, and providing fundamental data for researchers in relevant fields.
In this meta-analysis, a total of 799 articles, published as of 13 December 2016, were retrieved from Pubmed, Embase, Web of Science and Cochrane, and 11 of them were included after screening. The pooled estimates and factors which influence healthcare seeking rates were analysed.
The overall pooled healthcare seeking rate was 0.52 (95% CI: 0.46-0.59). The rate was significantly higher during the H1N1 pandemic in 2009 (0.61, 95% CI: 0.51-0.74), in children (0.56, 95% CI: 0.55-0.57) and in patients with documented fever (0.62, 95% CI: 0.53-0.72) than during non-pandemic periods (0.39, 95% CI: 0.33-0.45), in adults (0.45, 95% CI: 0.42-0.48) and in patients without documented fever (0.44, 95% CI: 0.38-0.50). Meta-regression indicated that these three factors could jointly explain 70.1% of the total heterogeneity among published studies.
The healthcare seeking rate of ILI patients is needed for estimation of the burden of ILI in the general population based on data from routine ILI sentinel surveillance systems.
并非所有患流感样疾病（ILI）的人都会寻求医疗服务。了解寻求医疗服务的比例对于评估与 ILI 相关的疾病（如季节性流感和人感染禽流感）的实际负担和病死率非常重要。有许多研究调查了寻求医疗服务的比率，但结果从 0.16 到 0.85 不等。我们进行了这项分析，以便更好地了解 ILI 患者寻求医疗服务的比率，并为相关领域的研究人员提供基本数据。
在这项荟萃分析中，共从 Pubmed、Embase、Web of Science 和 Cochrane 检索到 799 篇文章，截至 2016 年 12 月 13 日发表，经筛选后纳入 11 篇文章。分析了汇总估计值和影响寻求医疗服务率的因素。
总体上，ILI 患者寻求医疗服务的比率为 0.52（95%CI：0.46-0.59）。2009 年 H1N1 大流行期间（0.61，95%CI：0.51-0.74）、儿童（0.56，95%CI：0.55-0.57）和有记录发热的患者（0.62，95%CI：0.53-0.72）的比率显著高于非大流行期间（0.39，95%CI：0.33-0.45）、成人（0.45，95%CI：0.42-0.48）和无记录发热的患者（0.44，95%CI：0.38-0.50）。Meta 回归表明，这三个因素可以共同解释已发表研究中总异质性的 70.1%。
ILI 患者寻求医疗服务的比率是基于常规 ILI 哨点监测系统数据估计一般人群 ILI 负担所必需的。
