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一项新型数字研究中流感样疾病就医的预测因素

Predictors of Seeking Care for Influenza-Like Illness in a Novel Digital Study.

作者信息

Chawla Devika, Benitez Alejandra, Xu Hao, Whitehill Victoria, Tadesse-Bell Sara, Shapiro Allison, Ramirez Ernesto, Scherer Kelly, Foschini Luca, Drawnel Faye, Clinch Barry, Prunotto Marco, Ukachukwu Vincent

机构信息

Genentech, Inc., South San Francisco, California, USA.

F. Hoffmann-La Roche Ltd, Mississauga, Ontario, Canada.

出版信息

Open Forum Infect Dis. 2022 Dec 22;10(1):ofac675. doi: 10.1093/ofid/ofac675. eCollection 2023 Jan.

Abstract

BACKGROUND

Previous research has estimated that >50% of individuals experiencing influenza-like illness (ILI) do not seek health care. Understanding factors influencing care-seeking behavior for viral respiratory infections may help inform policies to improve access to care and protect public health. We used person-generated health data (PGHD) to identify factors associated with seeking care for ILI.

METHODS

Two observational studies (FluStudy2020, ISP) were conducted during the United States 2019-2020 influenza season. Participants self-reported ILI symptoms using the online Evidation platform. A log-binomial regression model was used to identify factors associated with seeking care.

RESULTS

Of 1667 participants in FluStudy2020 and 47 480 participants in ISP eligible for analysis, 518 (31.1%) and 11 426 (24.1%), respectively, sought health care. Participants were mostly female (92.2% FluStudy2020, 80.6% ISP) and aged 18-49 years (89.6% FluStudy2020, 89.8% ISP). In FluStudy2020, factors associated with seeking care included having health insurance (risk ratio [RR], 2.14; 95% CI, 1.30-3.54), more severe respiratory symptoms (RR, 1.53; 95% CI, 1.37-1.71), and comorbidities (RR, 1.37; 95% CI, 1.20-1.58). In ISP, the strongest predictor of seeking care was high symptom number (RR for 6/7 symptoms, 2.14; 95% CI, 1.93-2.38).

CONCLUSIONS

Using PGHD, we confirmed low rates of health care-seeking behavior for ILI and show that having health insurance, comorbidities, and a high symptom burden were associated with seeking health care. Reducing barriers in access to care for viral respiratory infections may lead to better disease management and contribute to protecting public health.

摘要

背景

先前的研究估计,超过50%出现流感样疾病(ILI)的个体未寻求医疗保健。了解影响病毒性呼吸道感染就医行为的因素可能有助于制定政策,以改善就医机会并保护公众健康。我们使用个人生成的健康数据(PGHD)来确定与ILI就医相关的因素。

方法

在美国2019 - 2020年流感季节期间进行了两项观察性研究(FluStudy2020和ISP)。参与者通过在线Evidation平台自我报告ILI症状。使用对数二项回归模型来确定与就医相关的因素。

结果

在FluStudy2020的1667名参与者和ISP的47480名符合分析条件的参与者中,分别有518名(31.1%)和11426名(24.1%)寻求了医疗保健。参与者大多为女性(FluStudy2020中为92.2%,ISP中为80.6%),年龄在18 - 49岁之间(FluStudy2020中为89.6%,ISP中为89.8%)。在FluStudy2020中,与就医相关的因素包括拥有医疗保险(风险比[RR],2.14;95%置信区间[CI],1.30 - 3.54)、更严重的呼吸道症状(RR,1.53;95% CI,1.37 - 1.71)以及合并症(RR,1.37;95% CI,1.20 - 1.58)。在ISP中,就医的最强预测因素是症状数量多(6/7种症状的RR,2.14;95% CI,1.93 - 2.38)。

结论

通过使用PGHD,我们证实了ILI的就医行为发生率较低,并表明拥有医疗保险、合并症和高症状负担与寻求医疗保健相关。减少病毒性呼吸道感染的就医障碍可能会带来更好的疾病管理,并有助于保护公众健康。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fd7/9850268/81c37b9e456a/ofac675f1.jpg

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