Dipartimento di Farmacia e Scienze della Salute e della Nutrizione, Università della Calabria, Edificio Polifunzionale- 87036 Rende (CS), Italy.
Curr Med Chem. 2019;26(31):5825-5848. doi: 10.2174/0929867325666180713150626.
Giving a glance to the report of Wound Care Market by Product updated in 2017, we can see that wound care market is expected to reach USD 22.01 billion by 2022 from USD 18.35 billion at a CAGR of 3.7%. Numerous factors are driving the growth of this market, including the increasing prevalence of chronic wounds and acute wounds, increasing aged population, rising R&D activities and advancement in the field of wound care research. Advanced wound management products are accounted for the largest market share in 2017. These evidences mean that the wound care research represents a Clinical Emergency other than an interesting Marketing tool. Drug therapies so far fight efficaciously with the opportunistic pathologies derived from chronic wounds, although an unsolved challenge is still finding a useful remedy to correct the impaired wound healing process and overcome the chronic wound state, to avoid bacterial rising and severe pain. Traditional medicinal plants have been widely used in the management of wounds and different plant extracts have been evaluated for their wound healing properties through both in vitro and in vivo studies. Their phytochemical components in particular quercetin, contribute to their remedial properties in wound repair. Quercetin has important biological activities related to the improvement of the wound healing process. The present review discusses and focuses on the latest findings of the wound healing properties of quercetin, alone or as a part of plant extract, and its role as a new frontier in wound repair.
浏览一下 2017 年更新的《伤口护理市场报告》，我们可以看到，预计到 2022 年，伤口护理市场将从 183.5 亿美元增长到 220.1 亿美元，复合年增长率为 3.7%。许多因素正在推动这一市场的增长，包括慢性伤口和急性伤口的患病率不断上升、人口老龄化、研发活动不断增加以及伤口护理研究领域的进步。先进的伤口管理产品在 2017 年占据了最大的市场份额。这些证据表明，伤口护理研究代表了一种临床急症，而不仅仅是一种有趣的营销工具。到目前为止，药物疗法有效地对抗了慢性伤口带来的机会性病理，但一个尚未解决的挑战是，仍在寻找一种有用的方法来纠正受损的伤口愈合过程，并克服慢性伤口状态，以避免细菌滋生和剧烈疼痛。传统药用植物已被广泛用于伤口管理，不同的植物提取物已通过体外和体内研究来评估其伤口愈合特性。它们的植物化学成分，特别是槲皮素，有助于其在伤口修复方面的治疗特性。槲皮素有与改善伤口愈合过程相关的重要生物活性。本文综述讨论并重点介绍了槲皮素单独或作为植物提取物的一部分的最新伤口愈合特性发现，以及它作为伤口修复新前沿的作用。
