Stanberry L R, Kern E R, Richards J T, Overall J C
Intervirology. 1985;24(4):226-31. doi: 10.1159/000149647.
After recovery from initial genital herpes simplex virus (HSV) infections, female guinea pigs developed spontaneous recurrent infections characterized by discrete erythematous or vesicular herpetic lesions on the external genital skin. HSV type 2 (HSV2) caused significantly more recurrent infections in guinea pigs than did HSV type 1 (HSV1). HSV2-infected animals demonstrated a significant decline in frequency of recurrences over time. The viral nature of the recurrent lesions was confirmed by recovery of infectious HSV, detection of HSV antigen, and histologic examination. Latent HSV2 could be demonstrated in dorsal root ganglia and external genital skin after recovery from the primary infection. Recurrent genital HSV infection in the guinea pig shares many features with recurrent genital herpes in humans and provides a model for studying the relationship between latency and recurrences and for exploring methods for control of recurrent disease.
在从初次单纯疱疹病毒（HSV）生殖器感染中恢复后，雌性豚鼠出现了自发性复发性感染，其特征为外生殖器皮肤出现离散的红斑或水疱性疱疹病变。与1型单纯疱疹病毒（HSV1）相比，2型单纯疱疹病毒（HSV2）在豚鼠中引起的复发性感染明显更多。随着时间的推移，感染HSV2的动物复发频率显著下降。通过回收具有传染性的HSV、检测HSV抗原以及组织学检查，证实了复发性病变的病毒性质。从原发性感染恢复后，可在背根神经节和外生殖器皮肤中检测到潜伏的HSV2。豚鼠复发性生殖器HSV感染与人类复发性生殖器疱疹有许多共同特征，为研究潜伏与复发之间的关系以及探索控制复发性疾病的方法提供了一个模型。
