Alspaugh M A, Miller J J
J Pediatr. 1977 Mar;90(3):391-5. doi: 10.1016/s0022-3476(77)80699-9.
The sera from 77 children with juvenile rheumatoid arthritis were studied for the presence of antinuclear antibodies, rheumatoid factor, and for antibodies to seven well-characterized nuclear antigens which occur in specific rheumatic diseases of adults. These included: Sm, RNP, DNA, RNA, RAP, SS-A, and SS-B. Forty-nine percent of the sera from patients with JRA contained ANA. The most common pattern was speckled. The frequency of all other positive tests was too low (13%) to make correlations with disease states. However, a small group of girls with polyarticular and late-onset disease had a high incidence of RF or RAP. These two antibodies were not associated with each other as they are in adult RA.
对77名青少年类风湿性关节炎患儿的血清进行了研究，以检测抗核抗体、类风湿因子以及针对七种已明确特征的核抗原的抗体，这些核抗原出现在成人特定的风湿性疾病中。这些核抗原包括：Sm、RNP、DNA、RNA、RAP、SS - A和SS - B。青少年类风湿性关节炎患者血清中49%含有抗核抗体。最常见的模式是斑点状。所有其他阳性检测的频率过低（13%），无法与疾病状态建立关联。然而，一小部分患有多关节和迟发性疾病的女孩类风湿因子或RAP的发生率较高。这两种抗体在这些患儿中并不像在成人类风湿性关节炎中那样相互关联。
