Rosenberg A M
Department of Pediatrics, University of Saskatchewan, Saskatoon, Canada.
Clin Immunol Immunopathol. 1988 Oct;49(1):19-27. doi: 10.1016/0090-1229(88)90091-8.
To clarify further the clinical correlates of antinuclear antibodies (ANA) in children with juvenile rheumatoid arthritis (JRA) this study compared the features of 60 ANA positive and 25 ANA negative children with JRA. ANA was more likely to be present in those with pauciarticular JRA than polyarticular JRA particularly if the ANA was of high titer. ANA positive subjects were more likely to have extraarticular manifestations, especially iridocyclitis. No significant differences were observed in onset ages, sex distribution, season of disease onset, family histories, or prognosis. There was no correlation between ANA titer and disease activity. Thus, while certain clinical features do correlate with ANA positivity in JRA, most clinical manifestations do not occur with distinctively different frequencies in the ANA negative and ANA positive groups.
为进一步阐明幼年类风湿关节炎（JRA）患儿抗核抗体（ANA）的临床相关因素，本研究比较了60例ANA阳性和25例ANA阴性的JRA患儿的特征。与多关节型JRA患儿相比，少关节型JRA患儿更易出现ANA，特别是高滴度ANA。ANA阳性患儿更易出现关节外表现，尤其是虹膜睫状体炎。在发病年龄、性别分布、发病季节、家族史或预后方面未观察到显著差异。ANA滴度与疾病活动度之间无相关性。因此，虽然某些临床特征确实与JRA患儿的ANA阳性相关，但大多数临床表现并未在ANA阴性组和ANA阳性组中以明显不同的频率出现。
