Cagetti Maria Grazia, Bontà Giuliana, Cocco Fabio, Lingstrom Peter, Strohmenger Laura, Campus Guglielmo
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Via Beldiletto 1, 20142, Milan, Italy.
WHO Collaboration Centre for Epidemiology and Community Dentistry, Via Beldiletto 1, 20142, Milan, Italy.
BMC Oral Health. 2018 Jul 16;18(1):123. doi: 10.1186/s12903-018-0585-4.
Assessing caries risk is an essential element in the planning of preventive and therapeutic strategies. Different caries risk assessment (CRA) models have been proposed for the identification of individuals running a risk of future caries. This systematic review was designed to evaluate whether standardized caries risk assessment (CRA) models are able to evaluate the risk according to the actual caries status and/or the future caries increment.
Randomized clinical trials, cross-sectional studies, cohort studies, comparative studies, validation studies and evaluation studies, reporting caries risk assessment using standardized models (Cariogram, CAMBRA, PreViser, NUS-CRA and CAT) in patients of any age related to caries data recorded by DMFT/S or ICDAS indices, were included. PubMed, Scopus and Embase were searched from 2000 to 2016. A search string was developed. All the papers meeting the inclusion criteria were subjected to a quality assessment.
One thousand three-undred ninety-two papers were identified and 32 were included. In all but one, the Cariogram was used both as sole model or in conjunction with other models. All the papers on children (n = 16) and adults (n = 12) found a statistically significant association between the risk levels and the actual caries status and/or the future caries increment. Nineteen papers, all using the Cariogram except one, were classified as being of good quality. Three of four papers comprising children and adults found a positive association. For seven of the included papers, Cariogram sensibility and specificity were calculated; sensibility ranged from low (41.0) to fairly low (75.0), while specificity was higher, ranging from 65.8 to 88.0. Wide 95% confidence intervals for both parameters were found, indicating that the reliability of the model differed in different caries risk levels.
The scientific evidence relating to standardized CRA models is still limited; even if Cariogram was tested in children and adults in few studies of good quality, no sufficient evidence is available to affirm the method is effective in caries assessment and prediction. New options of diagnosis, prognosis and therapy are now available to dentists but the validity of standardized CRA models still remains limited.
评估龋病风险是预防和治疗策略规划中的一个重要因素。已提出不同的龋病风险评估(CRA)模型用于识别有未来患龋风险的个体。本系统评价旨在评估标准化龋病风险评估(CRA)模型是否能够根据实际龋病状况和/或未来龋病增量来评估风险。
纳入随机临床试验、横断面研究、队列研究、比较研究、验证研究和评估研究,这些研究报告了在任何年龄患者中使用标准化模型(Cariogram、CAMBRA、PreViser、NUS - CRA和CAT)进行龋病风险评估,且与DMFT/S或ICDAS指数记录的龋病数据相关。检索了2000年至2016年期间的PubMed、Scopus和Embase。制定了检索词。所有符合纳入标准的论文都进行了质量评估。
共识别出1392篇论文,纳入32篇。除一篇外,其余所有论文均将Cariogram作为唯一模型或与其他模型联合使用。所有关于儿童(n = 16)和成人(n = 12)的论文均发现风险水平与实际龋病状况和/或未来龋病增量之间存在统计学显著关联。除一篇外,所有19篇使用Cariogram的论文被归类为质量良好。包含儿童和成人的四篇论文中有三篇发现存在正相关。对于纳入的七篇论文,计算了Cariogram的敏感性和特异性;敏感性范围从低(41.0)到相当低(75.0),而特异性较高,范围从65.8至到88.0。发现这两个参数的95%置信区间较宽,表明该模型在不同龋病风险水平下的可靠性存在差异。
与标准化CRA模型相关的科学证据仍然有限;即使在少数高质量研究中对儿童和成人进行了Cariogram测试,但仍没有足够证据证实该方法在龋病评估和预测中有效。现在牙医有了新的诊断、预后和治疗选择,但标准化CRA模型的有效性仍然有限。