New York University, New York City (I.J.G., E.A.F.).
University of California, Los Angeles (K.R.).
Circulation. 2018 Jul 17;138(3):305-315. doi: 10.1161/CIRCULATIONAHA.118.033704.
Lipid droplets (LDs) are distinct and dynamic organelles that affect the health of cells and organs. Much progress has been made in understanding how these structures are formed, how they interact with other cellular organelles, how they are used for storage of triacylglycerol in adipose tissue, and how they regulate lipolysis. Our understanding of the biology of LDs in the heart and vascular tissue is relatively primitive in comparison with LDs in adipose tissue and liver. The National Heart, Lung, and Blood Institute convened a working group to discuss how LDs affect cardiovascular diseases. The goal of the working group was to examine the current state of knowledge on the cell biology of LDs, including current methods to study them in cells and organs and reflect on how LDs influence the development and progression of cardiovascular diseases. This review summarizes the working group discussion and recommendations on research areas ripe for future investigation that will likely improve our understanding of atherosclerosis and heart function.
脂滴（LDs）是一种独特且动态的细胞器，会影响细胞和器官的健康。目前，人们已经在理解这些结构如何形成、如何与其他细胞细胞器相互作用、如何在脂肪组织中用于储存三酰基甘油以及如何调节脂肪分解等方面取得了很大进展。与脂肪组织和肝脏中的 LD 相比，我们对心脏和血管组织中 LD 的生物学了解相对较少。美国国立心肺血液研究所召集了一个工作组来讨论 LD 如何影响心血管疾病。该工作组的目标是检查 LD 细胞生物学的现有知识，包括当前在细胞和器官中研究它们的方法，并反思 LD 如何影响心血管疾病的发展和进展。这篇综述总结了工作组关于未来可能有助于提高我们对动脉粥样硬化和心脏功能理解的研究领域的讨论和建议。
