Raafat Karim, Habib Jean
Department of Pharmaceutical Sciences, Faculty of Pharmacy, Beirut Arab University.
Laboratoire De Recherche Et Développement Des Médicaments Et Des Produits Naturels, (RDMPN), EDST, Faculty of Pharmacy, Lebanese University.
J Oleo Sci. 2018 Aug 1;67(8):1015-1025. doi: 10.5650/jos.ess17187. Epub 2018 Jul 17.
Salvia sclarea (SS) is characterized by its valuable essential oils (Eos) and potent biological activities. This study aimed at investigating the phytochemical composition of SS Eos collected in within the same week, from two different regions in Lebanon, Beirut (SS-Bt) and Taanayel (SS-Tl), utilizing GC-MS methods, and to explore their acute and subchronic antidiabetic potentials. Moreover, studying the phytochemical diversity of twenty SS Eos established on our work and literature descriptions in order to recognize the origin of the Lebanese active chemotype(s). The Eos have been obtained by hydro-distillation and identified via GC-MS analyses. Five chemotypes of SS Eos have been identified. The Lebanese Eos, SS-Bt and SS-Tl, studied here have shown evidence to belong to two different chemotypes 1 and 5, respectively. SS-Bt has shown to belong to chemotype 1, which is characterized by high linalool (LL) concentration (average 40.2%). On the other hand, SS-Tl has shown to belong to chemotype 5, which is characterized by high linalyl acetate (LA) concentration (average 50.4%). The acute and subchronic antidiabetic activities of these EOs have been monitored along with LL and LA, in order to find the most active chemotype. Chemotypes 1 (owned to high LL content), present at low altitude places of Lebanon and Poland, has shown significantly higher acute and subchronic antidiabetic activities than that of chemotype 5 (owned to high LA content). In conclusion, Salvia sclarea Eos have shown potential antidiabetic activities, and their Eos might be used in the future as a complementary or an alternative medicine in the management of diabetes and related complications.
南欧丹参（Salvia sclarea，SS）以其珍贵的精油（EOs）和强大的生物活性为特征。本研究旨在利用气相色谱 - 质谱（GC - MS）方法，调查在同一周内从黎巴嫩两个不同地区贝鲁特（SS - Bt）和塔纳耶勒（SS - Tl）采集的南欧丹参精油的植物化学成分，并探索它们的急性和亚慢性抗糖尿病潜力。此外，根据我们的研究工作和文献描述，研究20种南欧丹参精油的植物化学多样性，以识别黎巴嫩活性化学型的来源。通过水蒸馏法获得精油，并通过GC - MS分析进行鉴定。已鉴定出南欧丹参精油的五种化学型。此处研究的黎巴嫩精油SS - Bt和SS - Tl已证明分别属于两种不同的化学型1和5。SS - Bt已证明属于化学型1，其特征是芳樟醇（LL）浓度高（平均40.2%）。另一方面，SS - Tl已证明属于化学型5，其特征是乙酸芳樟酯（LA）浓度高（平均50.4%）。这些精油的急性和亚慢性抗糖尿病活性与LL和LA一起进行了监测，以找出最具活性的化学型。化学型1（由于LL含量高）存在于黎巴嫩和波兰的低海拔地区，其急性和亚慢性抗糖尿病活性明显高于化学型5（由于LA含量高）。总之，南欧丹参精油已显示出潜在的抗糖尿病活性，其精油未来可能作为糖尿病及相关并发症管理中的补充或替代药物使用。
