Polin D, Ringer R K
Environ Health Perspect. 1978 Apr;23:283-90. doi: 10.1289/ehp.7823283.
Two experiments with light breed laying chickens fed polybrominated biphenyl (PBB) as FireMaster FF-1. The first involved feeding PBB at dietary levels of 0.2, 1, 5, 25, 125, 625, and 3125 ppm, the second involved levels of 30, 45, 60, 90, and 120. Each group had 24 hens, and each experiment had a control group of 24 hens. PBB diets were fed for 5 weeks. Feed intake, production, reproduction, tissue residues and viability of offspring were monitored during that time and a subsequent 8 weeks. Production, hatchability, and viability of offspring were significantly affected by feeding PBB at 45 ppm. Marked inanition occurred at levels of 625 and 3125 ppm, and there was some loss of feed intake at 125 ppm. There was a return to normal production and hatchability in 3 to 4 weeks after PBB withdrawal of diets with levels of 125 ppm or less. Dose--response lines are presented for PBB in muscle, liver, kidney, adipose tissue, and eggs. Withdrawal curves for PBB from these tissues are also given.
用多溴联苯（PBB）作为FireMaster FF-1对轻型蛋鸡进行了两项实验。第一项实验给鸡饲喂日粮水平分别为0.2、1、5、25、125、625和3125 ppm的PBB，第二项实验的水平分别为30、45、60、90和120 ppm。每组有24只母鸡，每项实验都有一个由24只母鸡组成的对照组。PBB日粮饲喂5周。在此期间及随后的8周内监测采食量、产蛋量、繁殖情况、组织残留量和后代的存活力。饲喂45 ppm的PBB对后代的产蛋量、孵化率和存活力有显著影响。在625和3125 ppm水平出现明显的食欲不振，在125 ppm水平采食量有所下降。日粮中PBB水平在125 ppm及以下的，停喂后3至4周产蛋量和孵化率恢复正常。给出了PBB在肌肉、肝脏、肾脏、脂肪组织和鸡蛋中的剂量-反应曲线。还给出了PBB从这些组织中的消除曲线。
