Kong Shuhong, Yue Xuewang, Kong Sheng, Ren Yujie
Department of Computed Tomography, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China.
Department of Ultrasound, Laiwu Central Hospital of Xinwen Mineral Group, Laiwu, Shandong 271103, P.R. China.
Oncol Lett. 2018 Aug;16(2):2434-2438. doi: 10.3892/ol.2018.8898. Epub 2018 Jun 5.
This study investigated the application effect of contrast-enhanced ultrasound (CEUS) and enhanced CT in diagnosis of liver cancer and response evaluation of radiofrequency ablation (RFA). A total of 60 patients with liver cancer were selected in Dongying People's Hospital from April 2016 to May 2017. All patients were subjected to CEUS and enhanced CT. With pathological examination as the gold standard, diagnostic consistency of the two methods was compared. After RFA, patients were subjected to CEUS and enhanced CT to assess the efficacy, and the consistency was compared. There was no significant difference in diagnostic accuracy between CEUS and CT (p>0.05). Area under the ROC curve of CEUS was 0.896, with a sensitivity of 91.2% and a specificity of 88.7%. The area under the ROC curve for enhanced CT diagnosis was 0.907, with a sensitivity of 91.8% and a specificity of 89.7%. No significant difference in the maximal cross sectional area of lesions was found between CEUS and enhanced CT, and there was no significant difference in evaluation of therapeutic efficiency between the methods (p>0.05) before and 1 and 3 months after treatment. Bland-Altman test showed that there was a strong consistency between CEUS and enhanced CT in the measured maximum cross-sectional area of lesions at 1 and 3 months after treatment. Linear regression analysis showed that maximum section cross-sectional area measured by CEUS was significantly correlated with that detected by enhanced CT (r=0.617). The results suggested that diagnostic efficiency of CEUS was similar to that of enhanced CT, and both showed high sensitivity and specificity. Two methods showed high consistency in evaluating the curative effect of RFA. CEUS can achieve real-time observation of focal blood flow perfusion, and was more economically affordable and convenient.
本研究探讨了超声造影（CEUS）与增强CT在肝癌诊断及射频消融（RFA）疗效评估中的应用效果。选取2016年4月至2017年5月东营市人民医院收治的60例肝癌患者。所有患者均接受CEUS及增强CT检查。以病理检查为金标准，比较两种检查方法的诊断一致性。RFA术后，患者接受CEUS及增强CT检查以评估疗效，并比较一致性。CEUS与CT的诊断准确性差异无统计学意义（p>0.05）。CEUS的ROC曲线下面积为0.896，灵敏度为91.2%，特异度为88.7%。增强CT诊断的ROC曲线下面积为0.907，灵敏度为91.8%，特异度为89.7%。CEUS与增强CT在病灶最大截面积方面差异无统计学意义，两种方法在治疗前及治疗后1个月和3个月的疗效评估中差异也无统计学意义（p>0.05）。Bland-Altman检验显示，治疗后1个月和3个月，CEUS与增强CT在测量的病灶最大截面积方面具有较强的一致性。线性回归分析显示，CEUS测量的最大截面积与增强CT检测的最大截面积显著相关（r=0.617）。结果表明，CEUS的诊断效率与增强CT相似，二者均具有较高的灵敏度和特异度。两种方法在评估RFA疗效方面具有高度一致性。CEUS能够实现对局部血流灌注的实时观察，且更经济实惠、方便易行。
