-芳基糖苷类冰重结晶抑制剂作为新型冷冻保护剂：结构-功能研究

Capicciotti Chantelle J, Mancini Ross S, Turner Tracey R, Koyama Toshie, Alteen Matthew G, Doshi Malay, Inada Takaaki, Acker Jason P, Ben Robert N

Department of Chemistry, University of Ottawa, D'Iorio Hall, 10 Marie Curie, Ottawa, Ontario K1N 6N5, Canada.

Canadian Blood Services, Centre for Innovation, 8249-114 Street NW, Edmonton, Alberta T6G 2R8, Canada.

ACS Omega. 2016 Oct 31;1(4):656-662. doi: 10.1021/acsomega.6b00163. Epub 2016 Oct 24.

Low-molecular-weight ice recrystallization inhibitors (IRIs) are ideal cryoprotectants that control the growth of ice and mitigate cell damage during freezing. Herein, we describe a detailed study correlating the ice recrystallization inhibition activity and the cryopreservation ability with the structure of -aryl-glycosides. Many effective IRIs are efficient cryoadditives for the freezing of red blood cells (RBCs). One effective cryoadditive did not inhibit ice recrystallization but instead inhibited ice nucleation, demonstrating the significance of inhibiting both processes and illustrating the importance of this emerging class of cryoprotectants.

低分子量冰重结晶抑制剂（IRI）是理想的冷冻保护剂，可在冷冻过程中控制冰的生长并减轻细胞损伤。在此，我们描述了一项详细研究，该研究将冰重结晶抑制活性和冷冻保存能力与芳基糖苷的结构相关联。许多有效的IRI是用于冷冻红细胞（RBC）的高效冷冻添加剂。一种有效的冷冻添加剂不抑制冰重结晶，而是抑制冰成核，这证明了抑制这两个过程的重要性，并说明了这类新兴冷冻保护剂的重要性。