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ASAIO J. 2018 Nov/Dec;64(6):715-720. doi: 10.1097/MAT.0000000000000714.
2
First results of HeartWare left ventricular assist device implantation with tunnelling of the outflow graft through the transverse sinus.经横窦进行流出道移植物隧道化植入HeartWare左心室辅助装置的初步结果。
Interact Cardiovasc Thorac Surg. 2017 Oct 1;25(4):503-508. doi: 10.1093/icvts/ivx124.
3
Left Ventricular Assist Device Therapy for Destination Therapy: Is Less Invasive Surgery a Safe Alternative?用于终末期治疗的左心室辅助装置疗法:微创手术是一种安全的替代方案吗?
Rev Esp Cardiol (Engl Ed). 2018 Jan;71(1):13-17. doi: 10.1016/j.rec.2017.03.023. Epub 2017 Jun 20.
4
Left Ventricular Assist Devices for Lifelong Support.左心室辅助装置用于终身支持。
J Am Coll Cardiol. 2017 Jun 13;69(23):2845-2861. doi: 10.1016/j.jacc.2017.04.031.
5
Intrapericardial Left Ventricular Assist Device for Advanced Heart Failure.经心室内左心室辅助装置治疗晚期心力衰竭。
N Engl J Med. 2017 Feb 2;376(5):451-460. doi: 10.1056/NEJMoa1602954.
6
Long-term support of patients receiving a left ventricular assist device for advanced heart failure: a follow-up analysis of the Registry to Evaluate the HeartWare Left Ventricular Assist System.晚期心力衰竭患者接受左心室辅助装置的长期支持:评估HeartWare左心室辅助系统注册研究的随访分析
Eur J Cardiothorac Surg. 2016 Nov;50(5):834-838. doi: 10.1093/ejcts/ezw224. Epub 2016 Jul 13.
7
HeartWare left ventricular assist device for the treatment of advanced heart failure.用于治疗晚期心力衰竭的HeartWare左心室辅助装置。
Future Cardiol. 2016 Jan;12(1):17-26. doi: 10.2217/fca.15.58. Epub 2015 Nov 24.
8
Seventh INTERMACS annual report: 15,000 patients and counting.国际机械循环辅助装置注册研究(INTERMACS)第七年度报告:15000例患者及仍在增加。
J Heart Lung Transplant. 2015 Dec;34(12):1495-504. doi: 10.1016/j.healun.2015.10.003. Epub 2015 Oct 8.
9
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10
[Left ventricular assistant devices for end-stage heart failure: report of two cases].[终末期心力衰竭的左心室辅助装置:两例报告]
Rev Med Chil. 2014 Jul;142(7):914-8. doi: 10.4067/S0034-98872014000700013.

智利的左心室辅助装置(LVAD)项目:南美洲的首次成功经验。

Left ventricular assist device (LVAD) program in Chile: first successful experience in South America.

作者信息

Pedemonte Oneglio, Vera Andres, Merello Lorenzo, Novajas Manuel, Aranda Fernando, Ibarra Julio, Muñoz Jose A, Alburquerque Javier, Espinoza Paulina, Cárdenas Felipe, Aránguiz-Santander Ernesto

机构信息

Department of Cardiovascular Surgery, Hospital Gustavo Fricke, Viña del Mar, Chile.

Department of Cardiovascular Diseases, Universidad de Valparaíso, Valparaíso, Chile.

出版信息

J Thorac Dis. 2018 Jun;10(Suppl 15):S1751-S1757. doi: 10.21037/jtd.2018.02.83.

DOI:10.21037/jtd.2018.02.83
PMID:30034848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6035952/
Abstract

BACKGROUND

The need to have a variety of tools to deal with end-stage heart failure (ES-HF), along with the limited heart transplantation availability encouraged us to create a pilot Left ventricular assist device (LVAD) program in a public health care system hospital in Chile.

METHODS

A retrospective analysis of the first nine patients of an ongoing LVAD program initiated on August 2013 was performed, completing an average of 30 months of follow-up. The most important events regarding to morbidity and mortality are described.

RESULTS

Nine patients with ES-HF underwent LVAD implantation surgery; one of them died 23 days after surgery and another died after 11 months. One patient successfully underwent heart transplantation after 16 months of HeartWare ventricular assist device (HVAD) support; the other six patients remain in the program and have an average follow-up of 846 days at the time of this study (range, 23-1,481 days). The survival rate at 6, 12 and 18 months follow-up was 89%, 78% and 78% respectively.

CONCLUSIONS

This new pioneering LVAD program in Chile has been successful and now constitutes a vital adjunct to all who work in heart transplantation and ES-HF programs. It offers an effective therapeutic alternative when there is a severe donor shortage, in cases of atypical blood types, emergencies, exceptional cases with contraindication for heart transplantation or when there is important donor-receiver size mismatch.

摘要

背景

由于需要有多种工具来应对终末期心力衰竭(ES-HF),同时心脏移植的可及性有限,这促使我们在智利的一家公共卫生保健系统医院开展了一项左心室辅助装置(LVAD)试点项目。

方法

对2013年8月启动的一个正在进行的LVAD项目的前9名患者进行回顾性分析,平均随访30个月。描述了与发病率和死亡率相关的最重要事件。

结果

9例ES-HF患者接受了LVAD植入手术;其中1例术后23天死亡,另1例在11个月后死亡。1例患者在接受HeartWare心室辅助装置(HVAD)支持16个月后成功接受了心脏移植;其他6例患者仍在该项目中,在本研究时平均随访846天(范围为23 - 1481天)。随访6个月、12个月和18个月时的生存率分别为89%、78%和78%。

结论

智利这个新的开创性LVAD项目取得了成功,现在已成为所有从事心脏移植和ES-HF项目工作人员的重要辅助手段。当供体严重短缺、血型不典型、紧急情况、心脏移植有禁忌的特殊病例或供受体大小严重不匹配时,它提供了一种有效的治疗选择。