Miller S C
Int J Radiat Biol Relat Stud Phys Chem Med. 1982 Jun;41(6):633-43. doi: 10.1080/09553008214550731.
The distribution and localization of 241Pu in the testes of rats, guinea-pigs and a dog were determined using light and electron microscope autoradiography. These species were used because of the variation in the morphology and ultrastructure exhibited in their testicular tissues. In all animals the 241Pu was localized in testicular interstitial tissue and little was evident in the seminiferous tubules. There were marked species differences in the percentage of interstitial tissue cells labelled with 241Pu; 18 per cent of the cells labelled in rats, 9 per cent in guinea-pigs and 6 per cent in the dog. Electron microscope autoradiography demonstrates that 241Pu is localized in macrophages of the interstitial tissue in all species and appears to be concentrated in the lysosomal system of the cell. Based on differences in the histology and microstructure of testicular interstitial tissues and the patterns of 241Pu incorporation in these species, implications for predicting plutonium localization in human tissue are discussed.
利用光学显微镜和电子显微镜放射自显影技术，测定了241钚在大鼠、豚鼠和狗睾丸中的分布与定位。选用这些物种是因为它们睾丸组织的形态和超微结构存在差异。在所有动物中，241钚定位于睾丸间质组织，而在生精小管中则很少见。用241钚标记的间质组织细胞百分比存在显著的物种差异；大鼠中标记细胞占18%，豚鼠中占9%，狗中占6%。电子显微镜放射自显影显示，在所有物种中，241钚定位于间质组织的巨噬细胞中，并且似乎集中在细胞的溶酶体系统中。基于睾丸间质组织的组织学和微观结构差异以及这些物种中241钚的掺入模式，讨论了预测钚在人体组织中定位的意义。
