[环状RNA在肺癌中的研究进展]
[Research Progress of Circular RNA in Lung Cancer].
作者信息
Mu Yinyu, Xie Fuyi
机构信息
Department of Clinical Laboratory, Ningbo Medical Center, Lihuili Hospital, Ningbo 315040, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2018 Jul 20;21(7):543-546. doi: 10.3779/j.issn.1009-3419.2018.07.07.
Lung cancer is one of the most important malignant tumors of human health and life in the world, and is the leading cause of death in the world. At present, it is believed that it is caused by many factors. Circular RNA (circRNA), as a class of non-coding RNA family, has covalently closed loop structure. CircRNA is abundant in different cells. CircRNAs due to the special structure, with a high degree of specificity, conservation and stability, may have a potential clinical value in the development of lung cancer. The biological function of circRNA is multi-faceted, including miRNA sponge, transcriptional and alternative splicing, protein coding , and so on. Currently, the role and mechanism of circRNA in lung cancer is not very clear. In this paper, the characteristics, function, mechanism and the role of circRNAs in the occurrence and development of lung cancer are reviewed. .
肺癌是世界上对人类健康和生命最重要的恶性肿瘤之一，也是全球主要的死因。目前，人们认为它是由多种因素引起的。环状RNA（circRNA）作为一类非编码RNA家族，具有共价闭合环状结构。circRNA在不同细胞中含量丰富。由于其特殊结构，circRNA具有高度的特异性、保守性和稳定性，可能在肺癌发生发展中具有潜在的临床价值。circRNA的生物学功能是多方面的，包括充当微小RNA（miRNA）海绵、转录和可变剪接、蛋白质编码等。目前，circRNA在肺癌中的作用和机制尚不完全清楚。本文对circRNA的特征、功能、机制及其在肺癌发生发展中的作用进行综述。
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