Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.
"Leon Daniello" Pneumology Clinic, Cluj-Napoca, Romania.
Wiley Interdiscip Rev RNA. 2020 Sep;11(5):e1592. doi: 10.1002/wrna.1592. Epub 2020 Mar 16.
Lung cancer is one of the main causes of cancer-related death in the world, especially due to its frequency and ineffective therapeutically approaches in the late stages of the disease. Despite the recent advent of promising new targeted therapies, lung cancer diagnostic strategies still have difficulty in identifying the disease at an early stage. Therefore, the characterizations of more sensible and specific cancer biomarkers have become an important goal for clinicians. Circular RNAs (circRNAs), a type of RNA with covalently closed continuous loop structures that display high structural resistance and tissue specificity pointed toward a potential biomarker role. Current investigations have identified that circRNAs have a prominent function in the regulation of oncogenic pathways, by regulating gene expression both at transcriptional and post-transcriptional level. The aim of this review is to provide novel information regarding the implications of circRNAs in lung cancer, with an emphasis on the role in disease development and progression. Initially, we explored the potential utility of circRNAs as biomarkers, focusing on function, mechanisms, and correlation with disease progression in lung cancer. Further, we will describe the interaction between circRNAs and other non-coding species of RNA (particularly microRNA) and their biological significance in lung cancer. Describing the nature of these interactions and their therapeutic potential will provide additional insight regarding the altered molecular landscape of lung cancer and consolidate the potential clinical value of these circular transcripts. This article is categorized under: RNA Structure and Dynamics > Influence of RNA Structure in Biological Systems RNA in Disease and Development > RNA in Disease RNA in Disease and Development > RNA in Development.
肺癌是全球癌症相关死亡的主要原因之一，尤其是由于其在疾病晚期的发病率高且治疗效果不佳。尽管最近出现了有前途的新靶向治疗方法，但肺癌诊断策略仍然难以在早期识别该疾病。因此，寻找更敏感和特异性的癌症生物标志物已成为临床医生的重要目标。环状 RNA（circRNA）是一种具有共价闭合连续环结构的 RNA，具有高度的结构稳定性和组织特异性，这表明其具有成为潜在生物标志物的作用。目前的研究已经确定，circRNA 通过在转录和转录后水平上调节基因表达，在调控致癌途径方面发挥着重要作用。本综述的目的是提供有关 circRNA 在肺癌中的作用的新信息，重点介绍其在疾病发展和进展中的作用。首先，我们探讨了 circRNA 作为生物标志物的潜在用途，重点关注其在肺癌中的功能、机制以及与疾病进展的相关性。此外，我们将描述 circRNA 与其他非编码 RNA（特别是 microRNA）之间的相互作用及其在肺癌中的生物学意义。描述这些相互作用及其治疗潜力将为肺癌改变的分子图谱提供更多的见解，并巩固这些环状转录物的潜在临床价值。本文属于以下分类：RNA 结构与动态 > RNA 结构对生物系统的影响 RNA 在疾病与发展中的作用 > RNA 在疾病中的作用 RNA 在疾病与发展中的作用 > RNA 在发展中的作用。
