[环状RNA在肺癌诊断、发展及耐药性中的作用]
[Role of Circular RNA in Diagnosis, Development and Durg Resistance of Lung Cancer].
作者信息
Chen Tianxiang, Yang Yunhai
机构信息
Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
出版信息
Zhongguo Fei Ai Za Zhi. 2019 Aug 20;22(8):532-536. doi: 10.3779/j.issn.1009-3419.2019.08.09.
The mortality rate of lung cancer has been high all over the world. In recent years, targeted drugs have become a new and effective method for the treatment of advanced lung cancer, but the early diagnosis and long-term effective treatment are still great challenges in lung cancer. Circular RNA (circRNA) is a unique RNA molecule with ring structure, which exhibits excellent stability and expression specificity. Increasing studies found that the expression of several circRNAs in tumors were abnormal. This abnormal expression is not only related to malignancy of tumors, but also involved in regulating the progress of tumors, which provides a new way for the diagnosis and treatment of tumors. Therefore, this article reviews the expression, the diagnostic and prognostic value as well as pathogenesis of circRNAs in lung cancer in order to find new targets for early diagnosis and treatment of lung cancer. .
肺癌的死亡率在全球范围内一直居高不下。近年来，靶向药物已成为治疗晚期肺癌的一种新的有效方法，但肺癌的早期诊断和长期有效治疗仍然面临巨大挑战。环状RNA（circRNA）是一种具有环状结构的独特RNA分子，具有出色的稳定性和表达特异性。越来越多的研究发现，几种circRNA在肿瘤中的表达异常。这种异常表达不仅与肿瘤的恶性程度有关，还参与调节肿瘤的进展，为肿瘤的诊断和治疗提供了新途径。因此，本文综述了circRNA在肺癌中的表达、诊断和预后价值以及发病机制，以期为肺癌的早期诊断和治疗寻找新靶点。
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