Saleh Jasmine
Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, United states.
Pathol Res Pract. 2018 Sep;214(9):1235-1238. doi: 10.1016/j.prp.2018.07.008. Epub 2018 Jul 11.
Melanoma is an aggressive and highly metastatic skin cancer, carrying a poor prognosis with a median survival time of 5.3-10 months depending on the stage of disease. Research has advanced our understanding of the underlying pathology of melanoma and strategies to prevent and treat melanoma. Mouse models have been developed to elucidate the molecular, immunological, and cellular mechanisms contributing to proliferation and metastasis of melanoma. This review article aims to provide an overview of various types of murine melanoma models, including xenograft and syngeneic transplantation models, genetically modified models, ultraviolent radiation models, and chemically induced models, and discuss the advantages and limitations of each model.
黑色素瘤是一种侵袭性强且具有高度转移性的皮肤癌，预后较差，根据疾病阶段不同，中位生存时间为5.3至10个月。研究增进了我们对黑色素瘤潜在病理学以及预防和治疗黑色素瘤策略的理解。已开发出小鼠模型来阐明促成黑色素瘤增殖和转移的分子、免疫和细胞机制。这篇综述文章旨在概述各种类型的小鼠黑色素瘤模型，包括异种移植和同基因移植模型、基因修饰模型、紫外线辐射模型以及化学诱导模型，并讨论每种模型的优缺点。
